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Discovery of a selective inhibitor of doublecortin like kinase 1.
Ferguson, Fleur M; Nabet, Behnam; Raghavan, Srivatsan; Liu, Yan; Leggett, Alan L; Kuljanin, Miljan; Kalekar, Radha L; Yang, Annan; He, Shuning; Wang, Jinhua; Ng, Raymond W S; Sulahian, Rita; Li, Lianbo; Poulin, Emily J; Huang, Ling; Koren, Jost; Dieguez-Martinez, Nora; Espinosa, Sergio; Zeng, Zhiyang; Corona, Cesear R; Vasta, James D; Ohi, Ryoma; Sim, Taebo; Kim, Nam Doo; Harshbarger, Wayne; Lizcano, Jose M; Robers, Matthew B; Muthaswamy, Senthil; Lin, Charles Y; Look, A Thomas; Haigis, Kevin M; Mancias, Joseph D; Wolpin, Brian M; Aguirre, Andrew J; Hahn, William C; Westover, Kenneth D; Gray, Nathanael S.
Afiliação
  • Ferguson FM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Nabet B; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Raghavan S; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Liu Y; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Leggett AL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Kuljanin M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Kalekar RL; Departments of Biochemistry and Radiation Oncology, the University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Yang A; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • He S; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Wang J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Ng RWS; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Sulahian R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Li L; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Poulin EJ; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Huang L; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Koren J; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Dieguez-Martinez N; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Espinosa S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Zeng Z; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Corona CR; Departments of Biochemistry and Radiation Oncology, the University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Vasta JD; Cancer Research Institute and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Ohi R; Cancer Research Institute and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Sim T; Department of Molecular and Human Genetics, Therapeutic Innovation Center Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA.
  • Kim ND; Departament de Bioquímica i Biologia Molecular & Institut de Neurociencies, Facultat de Medicina. Universitat Autonoma de Barcelona, Bellaterra, Spain.
  • Harshbarger W; Departament de Bioquímica i Biologia Molecular & Institut de Neurociencies, Facultat de Medicina. Universitat Autonoma de Barcelona, Bellaterra, Spain.
  • Lizcano JM; Promega Corporation, Madison, WI, USA.
  • Robers MB; Promega Corporation, Madison, WI, USA.
  • Muthaswamy S; Promega Corporation, Madison, WI, USA.
  • Lin CY; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Look AT; Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea and KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, Republic of Korea.
  • Haigis KM; NDBio Therapeutics Inc, Incheon, Republic of Korea.
  • Mancias JD; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Wolpin BM; GSK Vaccines, Rockville, MD, USA.
  • Aguirre AJ; Departament de Bioquímica i Biologia Molecular & Institut de Neurociencies, Facultat de Medicina. Universitat Autonoma de Barcelona, Bellaterra, Spain.
  • Hahn WC; Promega Corporation, Madison, WI, USA.
  • Westover KD; Cancer Research Institute and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Gray NS; Departments of Medicine and Pathology, Harvard Medical School, Boston, MA, USA.
Nat Chem Biol ; 16(6): 635-643, 2020 06.
Article em En | MEDLINE | ID: mdl-32251410
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Proteínas Serina-Treonina Quinases / Carcinoma Ductal Pancreático / Peptídeos e Proteínas de Sinalização Intracelular / Inibidores de Proteínas Quinases Limite: Animals / Humans / Male Idioma: En Revista: Nat Chem Biol Assunto da revista: BIOLOGIA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Proteínas Serina-Treonina Quinases / Carcinoma Ductal Pancreático / Peptídeos e Proteínas de Sinalização Intracelular / Inibidores de Proteínas Quinases Limite: Animals / Humans / Male Idioma: En Revista: Nat Chem Biol Assunto da revista: BIOLOGIA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos