Chloride accumulation in endosomes and lysosomes: facts checked in mice.
EMBO J
; 39(9): e104812, 2020 05 04.
Article
em En
| MEDLINE
| ID: mdl-32270512
ABSTRACT
Loss of the ClC-3 chloride/proton exchanger found in intracellular compartments leads to marked neurodegeneration. New genetic work by Weinert et al (2020) now shows that selective impairment of ClC-3's ion exchange activity is sufficient to elicit this severe phenotype in vivo. ClC-3 cooperates with the closely related ClC-4 in protecting endolysosomal chloride balance and neuronal integrity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prótons
/
Cloretos
Limite:
Animals
Idioma:
En
Revista:
EMBO J
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Alemanha