Aminoglycosides are efficient reagents to induce readthrough of premature termination codon in mutant B4GALNT1 genes found in families of hereditary spastic paraplegia.

Yesmin, Farhana; Bhuiyan, Robiul H; Ohmi, Yuhsuke; Ohkawa, Yuki; Tajima, Orie; Okajima, Tetsuya; Furukawa, Keiko; Furukawa, Koichi

Yesmin, Farhana; Bhuiyan, Robiul H; Ohmi, Yuhsuke; Ohkawa, Yuki; Tajima, Orie; Okajima, Tetsuya; Furukawa, Keiko; Furukawa, Koichi.

Afiliação

Yesmin F; Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, 1200 Matsumoto, Kasugai 487-8501, Japan.
Bhuiyan RH; Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya 466-0065, Japan.
Ohmi Y; Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, 1200 Matsumoto, Kasugai 487-8501, Japan.
Ohkawa Y; Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh.
Tajima O; Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, 1200 Matsumoto, Kasugai 487-8501, Japan.
Okajima T; Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, 1200 Matsumoto, Kasugai 487-8501, Japan.
Furukawa K; Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, 1200 Matsumoto, Kasugai 487-8501, Japan.
Furukawa K; Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya 466-0065, Japan.

J Biochem ; 168(2): 103-112, 2020 Aug 01.

Article em En | MEDLINE | ID: mdl-32282910

Assuntos

Aminoglicosídeos/farmacologia; Códon sem Sentido/efeitos dos fármacos; Códon de Terminação/efeitos dos fármacos; N-Acetilgalactosaminiltransferases/genética; Paraplegia Espástica Hereditária/genética; Animais; Células CHO; Células Cultivadas; Códon sem Sentido/genética; Códon de Terminação/genética; Cricetulus; Camundongos; Mutação

Palavras-chave

B4GALNT1; ganglioside; glycosyltransferase; hereditary spastic paraplegia; premature termination codon

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paraplegia Espástica Hereditária / N-Acetilgalactosaminiltransferases / Códon de Terminação / Códon sem Sentido / Aminoglicosídeos Limite: Animals Idioma: En Revista: J Biochem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão

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