CD300a identifies a CD4+ memory T cell subset with a higher susceptibility to HIV-1 infection.
AIDS
; 34(8): 1249-1252, 2020 07 01.
Article
em En
| MEDLINE
| ID: mdl-32287074
ABSTRACT
Human CD300a is known to promote the infection by dengue and other enveloped viruses and is overexpressed on CD4 T cells from HIV-1-infected patients. We found that infected CD4+RA- T cells from untreated HIV-1-infected patients were mostly CD300a+. Furthermore, CD300a expressing CD4+RA- T cells from healthy donors were significantly more infected by HIV-1 in vitro than CD300a- cells. CD300a might represent a biomarker of susceptibility to HIV-1 infection on memory CD4 T lymphocytes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Imunológicos
/
Linfócitos T CD4-Positivos
/
Antígenos CD
/
Infecções por HIV
/
HIV-1
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
AIDS
Assunto da revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
2020
Tipo de documento:
Article