Your browser doesn't support javascript.
loading
Fall/Fracture-Related Healthcare Costs and Their Association with Cumulative Anticholinergic Burden in People with Overactive Bladder.
Lozano-Ortega, Greta; Schermer, Carol R; Walker, David R; Szabo, Shelagh M; Rogula, Basia; Deighton, Alison M; Gooch, Katherine L; Campbell, Noll L.
Afiliação
  • Lozano-Ortega G; Broadstreet Health Economics and Outcomes Research, 203-343 Railway St, Vancouver, BC, V6A 1A4, Canada.
  • Schermer CR; Medical Affairs, Americas, Astellas Pharmaceutical Global Development Inc., Northbrook, IL, USA.
  • Walker DR; Medical Affairs, Americas, Astellas Pharmaceutical Global Development Inc., Northbrook, IL, USA.
  • Szabo SM; Broadstreet Health Economics and Outcomes Research, 203-343 Railway St, Vancouver, BC, V6A 1A4, Canada. sszabo@broadstreetheor.com.
  • Rogula B; Broadstreet Health Economics and Outcomes Research, 203-343 Railway St, Vancouver, BC, V6A 1A4, Canada.
  • Deighton AM; Broadstreet Health Economics and Outcomes Research, 203-343 Railway St, Vancouver, BC, V6A 1A4, Canada.
  • Gooch KL; Medical Affairs, Americas, Astellas Pharmaceutical Global Development Inc., Northbrook, IL, USA.
  • Campbell NL; College of Pharmacy, Purdue University, West Lafayette, IN, USA.
Pharmacoecon Open ; 5(1): 45-55, 2021 Mar.
Article em En | MEDLINE | ID: mdl-32291728
ABSTRACT

BACKGROUND:

Falls/fractures are major causes of morbidity and mortality among older adults and the resulting health consequences generate a substantial economic burden. Risk factors are numerous and include overactive bladder (OAB) and anticholinergic use.

OBJECTIVES:

We aimed to estimate the impact of falls/fractures on all-cause healthcare resource utilization and costs, according to levels of cumulative anticholinergic burden, among individuals with OAB.

METHODS:

Among a US cohort of adults with OAB (identified based on medical claims for OAB or OAB-specific medications), the frequency of resource utilization (outpatients visits, medication use, and hospitalizations) was examined according to level of anticholinergic burden. Anticholinergic burden was assessed cumulatively using a published measure, and categorized as no, low, medium, or high. Resource utilization prior to and after a fall/fracture was compared. Generalized linear models were used to examine overall and incremental changes in healthcare resource utilization and costs by fall/fracture status, and annual costs were predicted according to age, sex, fall/fracture status, and level of anticholinergic burden.

RESULTS:

The mean age of the OAB cohort (n = 154,432) was 56 years, 68% were female, and baseline mean anticholinergic burden was 266.7 (i.e. a medium level of burden); a fall/fracture was experienced by 9.9% of the cohort. All estimates of resource utilization were higher among those with higher levels of anticholinergic burden, regardless of fall/fracture status, and higher for all levels of anticholinergic burden after a fall/fracture. Among those with a fall/fracture, the highest predicted annual costs were observed among those aged 66-75 years with high anticholinergic burden (US$22,408 for males, US$22,752 for females).

CONCLUSIONS:

Falls/fractures were associated with higher costs, which increased with increasing anticholinergic burden.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Health_economic_evaluation / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Pharmacoecon Open Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Health_economic_evaluation / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Pharmacoecon Open Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá