Your browser doesn't support javascript.
loading
Predisposition to prolonged neutropenia after chemotherapy for paediatric acute myeloid leukaemia is associated with better prognosis in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study.
Aoki, Takahiro; Takahashi, Hiroyuki; Tanaka, Shiro; Shiba, Norio; Hasegawa, Daiichiro; Iwamoto, Shotaro; Terui, Kiminori; Moritake, Hiroshi; Nakayama, Hideki; Shimada, Akira; Koh, Katsuyoshi; Goto, Hiroaki; Kosaka, Yoshiyuki; Saito, Akiko M; Horibe, Keizo; Kinoshita, Akitoshi; Tawa, Akio; Taga, Takashi; Adachi, Souichi; Tomizawa, Daisuke.
Afiliação
  • Aoki T; Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Takahashi H; Department of Pediatrics, Toho University, Tokyo, Japan.
  • Tanaka S; Department of Clinical Biostatistics/Clinical Biostatistics Course, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Shiba N; Department of Pediatrics, Graduate School of Medicine, Yokohama City University Hospital, Yokohama, Japan.
  • Hasegawa D; Department of Hematology/Oncology, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan.
  • Iwamoto S; Department of Pediatrics, Mie University, Tsu, Japan.
  • Terui K; Department of Pediatrics, Hirosaki University, Hirosaki, Japan.
  • Moritake H; Division of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
  • Nakayama H; Department of Pediatrics, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.
  • Shimada A; Department of Pediatric Hematology/Oncology, Okayama University Hospital, Okayama, Japan.
  • Koh K; Department of Hematology/Oncology, Saitama Children's Medical Centre, Saitama, Japan.
  • Goto H; Division of Hematology/Oncology, Kanagawa Children's Medical Centre, Yokohama, Japan.
  • Kosaka Y; Department of Hematology/Oncology, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan.
  • Saito AM; Clinical Research Centre, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
  • Horibe K; Clinical Research Centre, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
  • Kinoshita A; Department of Pediatrics, School of Medicine, St. Marianna University, Kawasaki, Japan.
  • Tawa A; Higashiosaka Aramoto Heiwa Clinic, Higashiosaka, Japan.
  • Taga T; Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan.
  • Adachi S; Department of Human Health Science, Kyoto University, Kyoto, Japan.
  • Tomizawa D; Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Br J Haematol ; 193(1): 176-180, 2021 04.
Article em En | MEDLINE | ID: mdl-32337716
ABSTRACT
The variability in myelosuppression after chemotherapy for acute myeloid leukaemia (AML) can affect its prognosis; however, the underlying mechanism remains controversial. In the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study, we showed that prolonged neutropenia was associated with high overall survival (P = 0·011) and low frequency of relapse (P = 0·042) in patients without granulocyte-colony stimulating factor (G-CSF) who completed the indicated treatment protocol. Our data indicate that predisposition to prolonged neutropenia after chemotherapy is correlated with a better outcome of AML treatment. Our results promote the usage of individualised drug dosing strategies to improve the therapeutic outcome in AML patients.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Protocolos de Quimioterapia Combinada Antineoplásica / Fator Estimulador de Colônias de Granulócitos / Neutropenia Tipo de estudo: Guideline / Prognostic_studies / Risk_factors_studies Limite: Child / Female / Humans / Male País/Região como assunto: Asia Idioma: En Revista: Br J Haematol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Protocolos de Quimioterapia Combinada Antineoplásica / Fator Estimulador de Colônias de Granulócitos / Neutropenia Tipo de estudo: Guideline / Prognostic_studies / Risk_factors_studies Limite: Child / Female / Humans / Male País/Região como assunto: Asia Idioma: En Revista: Br J Haematol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão