Expanded clinical-grade membrane-bound IL-21/4-1BBL NK cell products exhibit activity against acute myeloid leukemia in vivo.

Zhao, Xiang-Yu; Jiang, Qian; Jiang, Hao; Hu, Li-Juan; Zhao, Ting; Yu, Xing-Xing; Huang, Xiao-Jun

Zhao, Xiang-Yu; Jiang, Qian; Jiang, Hao; Hu, Li-Juan; Zhao, Ting; Yu, Xing-Xing; Huang, Xiao-Jun.

Afiliação

Zhao XY; Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.
Jiang Q; Beijing Engineering Laboratory for Cellular Therapy, Beijing, China.
Jiang H; Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.
Hu LJ; Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.
Zhao T; Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.
Yu XX; Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.
Huang XJ; Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.

Eur J Immunol ; 50(9): 1374-1385, 2020 09.

Article em En | MEDLINE | ID: mdl-32357256

Assuntos

Células Matadoras Naturais/transplante; Leucemia Mieloide Aguda/terapia; Ligante 4-1BB/imunologia; Ligante 4-1BB/metabolismo; Adulto; Idoso; Animais; Feminino; Humanos; Interleucinas/imunologia; Interleucinas/metabolismo; Células K562; Células Matadoras Naturais/imunologia; Células Matadoras Naturais/metabolismo; Masculino; Camundongos; Pessoa de Meia-Idade; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

4-1BBL; Acute myeloid leukemia; IL-21; Minimal residual disease; NK cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Leucemia Mieloide Aguda Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Immunol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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