Intranasal Delivery and Transfection of mRNA Therapeutics in the Brain Using Cationic Liposomes.

Dhaliwal, Harkiranpreet Kaur; Fan, Yingfang; Kim, Jonghan; Amiji, Mansoor M

Dhaliwal, Harkiranpreet Kaur; Fan, Yingfang; Kim, Jonghan; Amiji, Mansoor M.

Afiliação

Dhaliwal HK; Department of Pharmaceutical Sciences, School of Pharmacy, Bouve College of Health Sciences, Northeastern University, Boston, Massachusetts 02115, United States.
Fan Y; Department of Pharmaceutical Sciences, School of Pharmacy, Bouve College of Health Sciences, Northeastern University, Boston, Massachusetts 02115, United States.
Kim J; Department of Pharmaceutical Sciences, School of Pharmacy, Bouve College of Health Sciences, Northeastern University, Boston, Massachusetts 02115, United States.
Amiji MM; Department of Pharmaceutical Sciences, School of Pharmacy, Bouve College of Health Sciences, Northeastern University, Boston, Massachusetts 02115, United States.

Mol Pharm ; 17(6): 1996-2005, 2020 06 01.

Article em En | MEDLINE | ID: mdl-32365295

Assuntos

Encéfalo/metabolismo; Cátions/química; RNA Mensageiro/administração & dosagem; RNA Mensageiro/metabolismo; Administração Intranasal; Animais; Linhagem Celular; Sistemas de Liberação de Medicamentos; Lipossomos/química; Masculino; Camundongos

Palavras-chave

brain delivery; cationic liposomes; intranasal administration; mRNA therapeutics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / RNA Mensageiro / Cátions Limite: Animals Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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