Tissue metabolic profiling shows that saccharopine accumulates during renal ischemic-reperfusion injury, while kynurenine and itaconate accumulate in renal allograft rejection.
Metabolomics
; 16(5): 65, 2020 05 04.
Article
em En
| MEDLINE
| ID: mdl-32367163
ABSTRACT
To examine metabolic differences between renal allograft acute cellular rejection (ACR) and ischemic-reperfusion injury (IRI), we transplanted MHC-mismatched kidneys and induced 28 min warm-IRI, and collected the ACR and IRI kidneys as well as their respective native and collateral control kidneys. We extracted metabolites from the kidney tissues and found the lysine catabolite saccharopine 12.5-fold enriched in IRI kidneys, as well as the immunometabolites itaconate and kynurenine in ACR kidneys. Saccharopine accumulation is known to be toxic to mitochondria and may contribute to IRI pathophysiology, while itaconate and kynurenine may be reflective of counterregulatory responses to immune activation in ACR.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Succinatos
/
Traumatismo por Reperfusão
/
Rejeição de Enxerto
/
Rim
/
Cinurenina
/
Lisina
Limite:
Animals
Idioma:
En
Revista:
Metabolomics
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos