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Irinotecan-mediated diarrhea is mainly correlated with intestinal exposure to SN-38: Critical role of gut Ugt.
Sun, Rongjin; Zhu, Lijun; Li, Li; Song, Wenjie; Gong, Xia; Qi, Xiaoxiao; Wang, Ying; Ghose, Romi; Gao, Song; Hu, Ming; Liu, Zhongqiu.
Afiliação
  • Sun R; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China; Department of Pharmacologic
  • Zhu L; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China.
  • Li L; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 4901 Calhoun Street, Houston, TX 77204, United States.
  • Song W; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China.
  • Gong X; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China.
  • Qi X; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China.
  • Wang Y; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China.
  • Ghose R; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 4901 Calhoun Street, Houston, TX 77204, United States.
  • Gao S; Department of Pharmaceutical and Environmental Health Sciences, Texas Southern University, 3100 Cleburne Street, Houston, TX 77004, United States. Electronic address: song.gao@tsu.edu.
  • Hu M; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 4901 Calhoun Street, Houston, TX 77204, United States. Electronic address: mhu4@central.uh.edu.
  • Liu Z; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China. Electronic address: liuzq@g
Toxicol Appl Pharmacol ; 398: 115032, 2020 07 01.
Article em En | MEDLINE | ID: mdl-32387182
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glucuronosiltransferase / Diarreia / Irinotecano / Intestinos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glucuronosiltransferase / Diarreia / Irinotecano / Intestinos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2020 Tipo de documento: Article