A Novel Function for KLF4 in Modulating the De-differentiation of EpCAM-/CD133- nonStem Cells into EpCAM+/CD133+ Liver Cancer Stem Cells in HCC Cell Line HuH7.

Karagonlar, Zeynep Firtina; Akbari, Soheil; Karabicici, Mustafa; Sahin, Eren; Avci, Sanem Tercan; Ersoy, Nevin; Ates, Kivilcim Eren; Balli, Tugsan; Karacicek, Bilge; Kaplan, Kubra Nur; Celiker, Canan; Atabey, Nese; Erdal, Esra

A Novel Function for KLF4 in Modulating the De-differentiation of EpCAM^-/CD133^- nonStem Cells into EpCAM⁺/CD133⁺ Liver Cancer Stem Cells in HCC Cell Line HuH7.

Karagonlar, Zeynep Firtina; Akbari, Soheil; Karabicici, Mustafa; Sahin, Eren; Avci, Sanem Tercan; Ersoy, Nevin; Ates, Kivilcim Eren; Balli, Tugsan; Karacicek, Bilge; Kaplan, Kubra Nur; Celiker, Canan; Atabey, Nese; Erdal, Esra.

Afiliação

Karagonlar ZF; Genetics and Bioengineering Department, Izmir University of Economics, 35330 Izmir, Turkey.
Akbari S; Department of Medical Biology and Genetics, Faculty of Medicine, Dokuz Eylul University, 35340 Izmir, Turkey.
Karabicici M; Department of Medical Biology and Genetics, Faculty of Medicine, Dokuz Eylul University, 35340 Izmir, Turkey.
Sahin E; Izmir Biomedicine and Genome Center, 35340 Izmir, Turkey.
Avci ST; Izmir Biomedicine and Genome Center, 35340 Izmir, Turkey.
Ersoy N; Department of Medical Biology and Genetics, Faculty of Medicine, Dokuz Eylul University, 35340 Izmir, Turkey.
Ates KE; Izmir Biomedicine and Genome Center, 35340 Izmir, Turkey.
Balli T; Department of Medical Biology and Genetics, Faculty of Medicine, Dokuz Eylul University, 35340 Izmir, Turkey.
Karacicek B; Izmir Biomedicine and Genome Center, 35340 Izmir, Turkey.
Kaplan KN; Izmir Biomedicine and Genome Center, 35340 Izmir, Turkey.
Celiker C; Department of Histology and Embryology, Faculty of Medicine, Dokuz Eylul University, 35340 Izmir, Turkey.
Atabey N; Department of Pathology, Faculty of Medicine, Cukurova University, 01260 Adana, Turkey.
Erdal E; Department of Radiology, Faculty of Medicine, Cukurova University, 01260 Adana, Turkey.

Cells ; 9(5)2020 05 12.

Article em En | MEDLINE | ID: mdl-32408542

Assuntos

Antígeno AC133/metabolismo; Carcinoma Hepatocelular/patologia; Desdiferenciação Celular; Molécula de Adesão da Célula Epitelial/metabolismo; Fatores de Transcrição Kruppel-Like/metabolismo; Neoplasias Hepáticas/patologia; Células-Tronco Neoplásicas/metabolismo; Animais; Caderinas/metabolismo; Carcinogênese/metabolismo; Carcinogênese/patologia; Carcinoma Hepatocelular/metabolismo; Linhagem Celular Tumoral; Membrana Celular/metabolismo; Molécula de Adesão da Célula Epitelial/genética; Humanos; Fator 4 Semelhante a Kruppel; Neoplasias Hepáticas/metabolismo; Camundongos Endogâmicos NOD; Camundongos SCID; Células-Tronco Neoplásicas/patologia; Fenótipo; Transcrição Gênica; beta Catenina/metabolismo

Palavras-chave

EpCAM; KLF4; hepatocellular carcinoma (HCC); liver cancer stem cells; reprogramming; tumor plasticity

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Carcinoma Hepatocelular / Fatores de Transcrição Kruppel-Like / Desdiferenciação Celular / Antígeno AC133 / Molécula de Adesão da Célula Epitelial / Neoplasias Hepáticas Limite: Animals / Humans Idioma: En Revista: Cells Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Turquia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google