Ring-Substituted 1-Hydroxynaphthalene-2-Carboxanilides Inhibit Proliferation and Trigger Mitochondria-Mediated Apoptosis.

Kauerová, Tereza; Gonec, Tomás; Jampílek, Josef; Hafner, Susanne; Gaiser, Ann-Kathrin; Syrovets, Tatiana; Fedr, Radek; Soucek, Karel; Kollar, Peter

Kauerová, Tereza; Gonec, Tomás; Jampílek, Josef; Hafner, Susanne; Gaiser, Ann-Kathrin; Syrovets, Tatiana; Fedr, Radek; Soucek, Karel; Kollar, Peter.

Afiliação

Kauerová T; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Masaryk University, Palackeho tr. 1946/1, 612 42 Brno, Czech Republic.
Gonec T; Department of Chemical Drugs, Faculty of Pharmacy, Masaryk University, Palackeho tr. 1946/1, 612 42 Brno, Czech Republic.
Jampílek J; Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska cesta 9, 845 10 Bratislava, Slovakia.
Hafner S; Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Helmholtzstraße 20, 89081 Ulm, Germany.
Gaiser AK; Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Helmholtzstraße 20, 89081 Ulm, Germany.
Syrovets T; Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Helmholtzstraße 20, 89081 Ulm, Germany.
Fedr R; Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Kralovopolska 135, 612 65 Brno, Czech Republic.
Soucek K; Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Kralovopolska 135, 612 65 Brno, Czech Republic.
Kollar P; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Masaryk University, Palackeho tr. 1946/1, 612 42 Brno, Czech Republic.

Int J Mol Sci ; 21(10)2020 May 12.

Article em En | MEDLINE | ID: mdl-32408543

Assuntos

Anilidas/farmacologia; Apoptose/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Mitocôndrias/efeitos dos fármacos; Naftóis/química; Anilidas/química; Antineoplásicos/química; Antineoplásicos/farmacologia; Ciclo Celular/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Humanos; Células MCF-7; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Mitocôndrias/metabolismo; Estrutura Molecular; Espécies Reativas de Oxigênio/metabolismo; Salicilanilidas/química; Salicilanilidas/farmacologia; Relação Estrutura-Atividade; Superóxidos/metabolismo; Células THP-1

Palavras-chave

antiproliferative effect; apoptosis; cell cycle; hydroxynaphthalene carboxamides; salicylanilides

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apoptose / Proliferação de Células / Anilidas / Mitocôndrias / Naftóis Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: República Tcheca

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