Acyltransferase-mediated selection of the length of the fatty acyl chain and of the acylation site governs activation of bacterial RTX toxins.

Osickova, Adriana; Khaliq, Humaira; Masin, Jiri; Jurnecka, David; Sukova, Anna; Fiser, Radovan; Holubova, Jana; Stanek, Ondrej; Sebo, Peter; Osicka, Radim

Osickova, Adriana; Khaliq, Humaira; Masin, Jiri; Jurnecka, David; Sukova, Anna; Fiser, Radovan; Holubova, Jana; Stanek, Ondrej; Sebo, Peter; Osicka, Radim.

Afiliação

Osickova A; Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.
Khaliq H; Department of Biochemistry, Faculty of Science, Charles University in Prague, Prague, Czech Republic.
Masin J; Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.
Jurnecka D; Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.
Sukova A; Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.
Fiser R; Department of Biochemistry, Faculty of Science, Charles University in Prague, Prague, Czech Republic.
Holubova J; Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.
Stanek O; Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.
Sebo P; Department of Genetics and Microbiology, Faculty of Science, Charles University in Prague, Prague, Czech Republic.
Osicka R; Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.

J Biol Chem ; 295(28): 9268-9280, 2020 07 10.

Article em En | MEDLINE | ID: mdl-32461253

Assuntos

Aciltransferases/metabolismo; Bactérias/metabolismo; Proteínas de Bactérias/metabolismo; Ácidos Graxos/metabolismo; Proteínas Hemolisinas/metabolismo; Animais; Linhagem Celular; Camundongos

Palavras-chave

RTX toxin; acylation; acyltransferase; adenylate cyclase toxin (CyaA); bacterial toxin; cytotoxicity; cytotoxin (RtxA); fatty acid; fatty acyl; posttranslational modification; protein acylation; protein translocation; protoxin; α-hemolysin (HlyA)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias / Proteínas de Bactérias / Aciltransferases / Ácidos Graxos / Proteínas Hemolisinas Limite: Animals Idioma: En Revista: J Biol Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: República Tcheca

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