Granzyme B is correlated with clinical outcome after PD-1 blockade in patients with stage IV non-small-cell lung cancer.

Hurkmans, Daan P; Basak, Edwin A; Schepers, Nina; Oomen-De Hoop, Esther; Van der Leest, Cor H; El Bouazzaoui, Samira; Bins, Sander; Koolen, Stijn L W; Sleijfer, Stefan; Van der Veldt, Astrid A M; Debets, Reno; Van Schaik, Ron H N; Aerts, Joachim G J V; Mathijssen, Ron H J

Hurkmans, Daan P; Basak, Edwin A; Schepers, Nina; Oomen-De Hoop, Esther; Van der Leest, Cor H; El Bouazzaoui, Samira; Bins, Sander; Koolen, Stijn L W; Sleijfer, Stefan; Van der Veldt, Astrid A M; Debets, Reno; Van Schaik, Ron H N; Aerts, Joachim G J V; Mathijssen, Ron H J.

Afiliação

Hurkmans DP; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands d.hurkmans@erasmusmc.nl.
Basak EA; Department of Pulmonology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Schepers N; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Oomen-De Hoop E; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Van der Leest CH; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
El Bouazzaoui S; Department of Pulmonology, Amphia Hospital, Breda, The Netherlands.
Bins S; Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, The Netherlands.
Koolen SLW; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Sleijfer S; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Van der Veldt AAM; Departmemt of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands.
Debets R; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Van Schaik RHN; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Aerts JGJV; Department of Radiology & Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Mathijssen RHJ; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

J Immunother Cancer ; 8(1)2020 05.

Article em En | MEDLINE | ID: mdl-32461348

Assuntos

Biomarcadores Tumorais/genética; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Granzimas/genética; Inibidores de Checkpoint Imunológico/farmacologia; Neoplasias Pulmonares/tratamento farmacológico; Adulto; Idoso; Idoso de 80 Anos ou mais; Biomarcadores Tumorais/sangue; Carcinoma Pulmonar de Células não Pequenas/genética; Carcinoma Pulmonar de Células não Pequenas/imunologia; Carcinoma Pulmonar de Células não Pequenas/mortalidade; Resistencia a Medicamentos Antineoplásicos/genética; Feminino; Granzimas/sangue; Humanos; Inibidores de Checkpoint Imunológico/uso terapêutico; Pulmão/imunologia; Pulmão/patologia; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/imunologia; Neoplasias Pulmonares/mortalidade; Masculino; Pessoa de Meia-Idade; Mutação; Estadiamento de Neoplasias; Nivolumabe/farmacologia; Nivolumabe/uso terapêutico; Polimorfismo de Nucleotídeo Único; Prognóstico; Receptor de Morte Celular Programada 1/antagonistas & inibidores; Receptor de Morte Celular Programada 1/imunologia; Intervalo Livre de Progressão; Estudos Prospectivos; Critérios de Avaliação de Resposta em Tumores Sólidos

Palavras-chave

genetic markers; immunotherapy; lung neoplasms; programmed cell death 1 receptor; translational medical research

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Carcinoma Pulmonar de Células não Pequenas / Granzimas / Inibidores de Checkpoint Imunológico / Neoplasias Pulmonares Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Immunother Cancer Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Holanda

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