Sequence-Independent Self-Assembly of Germ Granule mRNAs into Homotypic Clusters.

Trcek, Tatjana; Douglas, Tyler E; Grosch, Markus; Yin, Yandong; Eagle, Whitby V I; Gavis, Elizabeth R; Shroff, Hari; Rothenberg, Eli; Lehmann, Ruth

Trcek, Tatjana; Douglas, Tyler E; Grosch, Markus; Yin, Yandong; Eagle, Whitby V I; Gavis, Elizabeth R; Shroff, Hari; Rothenberg, Eli; Lehmann, Ruth.

Afiliação

Trcek T; HHMI, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, NYU School of Medicine, New York, NY, USA. Electronic address: ttrcekp1@jhu.edu.
Douglas TE; HHMI, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, NYU School of Medicine, New York, NY, USA.
Grosch M; HHMI, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, NYU School of Medicine, New York, NY, USA.
Yin Y; Department of Biochemistry and Pharmacology, NYU School of Medicine, New York, NY, USA.
Eagle WVI; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
Gavis ER; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
Shroff H; Section on High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD, USA.
Rothenberg E; Department of Biochemistry and Pharmacology, NYU School of Medicine, New York, NY, USA.
Lehmann R; HHMI, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, NYU School of Medicine, New York, NY, USA. Electronic address: ruth.lehmann@med.nyu.edu.

Mol Cell ; 78(5): 941-950.e12, 2020 06 04.

Article em En | MEDLINE | ID: mdl-32464092

Assuntos

Grânulos Citoplasmáticos/fisiologia; RNA Mensageiro/genética; Ribonucleoproteínas/metabolismo; Animais; Grânulos Citoplasmáticos/genética; Proteínas de Drosophila/genética; Drosophila melanogaster/genética; Proteínas Nucleares/metabolismo; Organelas/fisiologia; RNA/genética; Transporte de RNA/genética; RNA Mensageiro/metabolismo; Ribonucleoproteínas/genética

Palavras-chave

RNA clusters; RNA granules; RNA phase separation; RNA self-assembly; RNA sorting; RNA:RNA interactions; germ granules; homotypic RNA assembly; nanos; oskar

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribonucleoproteínas / RNA Mensageiro / Grânulos Citoplasmáticos Limite: Animals Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2020 Tipo de documento: Article

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