ProBDNF promotes sepsis-associated encephalopathy in mice by dampening the immune activity of meningeal CD4<sup>+</sup> T cells.

Luo, Ru-Yi; Luo, Cong; Zhong, Feng; Shen, Wei-Yun; Li, Hui; Hu, Zhao-Lan; Dai, Ru-Ping

ProBDNF promotes sepsis-associated encephalopathy in mice by dampening the immune activity of meningeal CD4⁺ T cells.

Luo, Ru-Yi; Luo, Cong; Zhong, Feng; Shen, Wei-Yun; Li, Hui; Hu, Zhao-Lan; Dai, Ru-Ping.

Afiliação

Luo RY; Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Central Ren-Min Road No. 139, Changsha, Hunan Province, China.
Luo C; Anesthesia Medical Research Center, Central South University, Changsha, China.
Zhong F; Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Central Ren-Min Road No. 139, Changsha, Hunan Province, China.
Shen WY; Anesthesia Medical Research Center, Central South University, Changsha, China.
Li H; Anesthesia Medical Research Center, Central South University, Changsha, China.
Hu ZL; Department of Anesthesiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Dai RP; Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Central Ren-Min Road No. 139, Changsha, Hunan Province, China.

J Neuroinflammation ; 17(1): 169, 2020 May 28.

Article em En | MEDLINE | ID: mdl-32466783

Assuntos

Fator Neurotrófico Derivado do Encéfalo/imunologia; Linfócitos T CD4-Positivos/imunologia; Meninges/imunologia; Precursores de Proteínas/imunologia; Encefalopatia Associada a Sepse/imunologia; Animais; Fator Neurotrófico Derivado do Encéfalo/metabolismo; Lipopolissacarídeos/toxicidade; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Precursores de Proteínas/metabolismo; Encefalopatia Associada a Sepse/induzido quimicamente; Encefalopatia Associada a Sepse/metabolismo

Palavras-chave

Brain-derived neurotrophic factor precursor; CD4+ T cells; Encephalopathy; Meningeal immunity; Monoclonal antibody; Sepsis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Precursores de Proteínas / Linfócitos T CD4-Positivos / Fator Neurotrófico Derivado do Encéfalo / Encefalopatia Associada a Sepse / Meninges Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: J Neuroinflammation Assunto da revista: NEUROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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