Novel dose escalation to predict treatment with hydroxyurea (NDEPTH): A randomized controlled trial of a dose-prediction equation to determine maximum tolerated dose of hydroxyurea in pediatric sickle cell disease.

George, Alex; Dinu, Bogdan; Estrada, Norma; Minard, Charles G; Hurwitz, Richard; Mahoney, Donald H; Yates, Amber M; Vaughan, Mary; Carmouche, Alaundra; Airewele, Gladstone; Kirk, Susan E; Fasipe, Titilope; Uwaezuoke, Precious; Ware, Russell E

George, Alex; Dinu, Bogdan; Estrada, Norma; Minard, Charles G; Hurwitz, Richard; Mahoney, Donald H; Yates, Amber M; Vaughan, Mary; Carmouche, Alaundra; Airewele, Gladstone; Kirk, Susan E; Fasipe, Titilope; Uwaezuoke, Precious; Ware, Russell E.

Afiliação

George A; Department of Pediatrics, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas, USA.
Dinu B; Department of Pediatrics, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas, USA.
Estrada N; Department of Pediatrics, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas, USA.
Minard CG; Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, Texas, USA.
Hurwitz R; Department of Pediatrics, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas, USA.
Mahoney DH; Department of Pediatrics, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas, USA.
Yates AM; Department of Pediatrics, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas, USA.
Vaughan M; Department of Pediatrics, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas, USA.
Carmouche A; Department of Pediatrics, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas, USA.
Airewele G; Department of Pediatrics, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas, USA.
Kirk SE; Department of Pediatrics, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas, USA.
Fasipe T; Department of Pediatrics, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas, USA.
Uwaezuoke P; Department of Pediatrics, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas, USA.
Ware RE; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Am J Hematol ; 95(9): E242-E244, 2020 09.

Article em En | MEDLINE | ID: mdl-32472611

Assuntos

Anemia Falciforme/tratamento farmacológico; Hidroxiureia/administração & dosagem; Dose Máxima Tolerável; Adolescente; Anemia Falciforme/mortalidade; Criança; Feminino; Humanos; Hidroxiureia/efeitos adversos; Masculino

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dose Máxima Tolerável / Hidroxiureia / Anemia Falciforme Tipo de estudo: Clinical_trials / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Am J Hematol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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