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Predisposition to superimposed preeclampsia in women with chronic hypertension: endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort.
Bramham, Kate; Villa, Pia M; Joslin, Jennifer R; Laivuori, Hannele; Hämäläinen, Esa; Kajantie, Eero; Räikkönen, Katri; Pesonen, Anukatriina; Seed, Paul; Dalton, R Neil; Turner, Charles; Wong, Max; Von Dadelszen, Peter; Roberts, James M; Poston, Lucilla; Chappell, Lucy C.
Afiliação
  • Bramham K; Department of Women and Children's Health, School of Life Course Sciences, King's College London , London, UK.
  • Villa PM; Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital , Helsinki, Finland.
  • Joslin JR; Department of Renal Sciences, School of Immunology and Microbial Sciences, King's College London , London, UK.
  • Laivuori H; Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital , Helsinki, Finland.
  • Hämäläinen E; Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital , Helsinki, Finland.
  • Kajantie E; Institute for Molecular Medicine Finland, University of Helsinki , Helsinki, Finland.
  • Räikkönen K; Clinical Chemistry, University of Helsinki and Helsinki University Hospital , Helsinki, Finland.
  • Pesonen A; Department of Health, National Institute for Health and Welfare , Helsinki, Finland.
  • Seed P; Children's Hospital, University of Helsinki and Helsinki University Hospital , Helsinki, Finland.
  • Dalton RN; Institute of Behavioral Sciences, University Of Helsinki , Helsinki, Finland.
  • Turner C; Institute of Behavioral Sciences, University Of Helsinki , Helsinki, Finland.
  • Wong M; Department of Women and Children's Health, School of Life Course Sciences, King's College London , London, UK.
  • Von Dadelszen P; WellChild Laboratory, King's College London and King's Health Partners , London, UK.
  • Roberts JM; WellChild Laboratory, King's College London and King's Health Partners , London, UK.
  • Poston L; WellChild Laboratory, King's College London and King's Health Partners , London, UK.
  • Chappell LC; Department of Women and Children's Health, School of Life Course Sciences, King's College London , London, UK.
Hypertens Pregnancy ; 39(3): 326-335, 2020 Aug.
Article em En | MEDLINE | ID: mdl-32479208
ABSTRACT

OBJECTIVE:

To assess the contribution of maternal and placental factors to the development of superimposed preeclampsia in women with chronic hypertension.

METHODS:

Endothelial and renal function markers were serially assessed in 90 pregnant women with chronic hypertension and controls.

RESULTS:

Syndecan-1 concentrations were lower at 26-27+6 weeks in women with chronic hypertension who subsequently developed superimposed preeclampsia compared with those who did not. Decreased PlGF and raised urine albumincreatinine ratio were also associated with development of superimposed preeclampsia.

CONCLUSION:

Decreased syndecan-1 and PlGF concentrations implicate endothelial glycocalyx disturbance and reduced placental angiogenic capacity, respectively, in the pathophysiology of superimposed preeclampsia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pré-Eclâmpsia / Receptor 1 de Fatores de Crescimento do Endotélio Vascular / Fator de Crescimento Placentário / Hipertensão Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Hypertens Pregnancy Assunto da revista: ANGIOLOGIA / OBSTETRICIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pré-Eclâmpsia / Receptor 1 de Fatores de Crescimento do Endotélio Vascular / Fator de Crescimento Placentário / Hipertensão Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Hypertens Pregnancy Assunto da revista: ANGIOLOGIA / OBSTETRICIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido