Predisposition to superimposed preeclampsia in women with chronic hypertension: endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort.
Hypertens Pregnancy
; 39(3): 326-335, 2020 Aug.
Article
em En
| MEDLINE
| ID: mdl-32479208
ABSTRACT
OBJECTIVE:
To assess the contribution of maternal and placental factors to the development of superimposed preeclampsia in women with chronic hypertension.METHODS:
Endothelial and renal function markers were serially assessed in 90 pregnant women with chronic hypertension and controls.RESULTS:
Syndecan-1 concentrations were lower at 26-27+6 weeks in women with chronic hypertension who subsequently developed superimposed preeclampsia compared with those who did not. Decreased PlGF and raised urine albumincreatinine ratio were also associated with development of superimposed preeclampsia.CONCLUSION:
Decreased syndecan-1 and PlGF concentrations implicate endothelial glycocalyx disturbance and reduced placental angiogenic capacity, respectively, in the pathophysiology of superimposed preeclampsia.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
/
Receptor 1 de Fatores de Crescimento do Endotélio Vascular
/
Fator de Crescimento Placentário
/
Hipertensão
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Hypertens Pregnancy
Assunto da revista:
ANGIOLOGIA
/
OBSTETRICIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Reino Unido