Methylsulfonylmethane Exhibits Bacteriostatic Inhibition of Vancomycin-Resistant Enterococcus faecium, In Vitro.
Microb Drug Resist
; 27(1): 13-17, 2021 Jan.
Article
em En
| MEDLINE
| ID: mdl-32522082
ABSTRACT
The aim of this study was to evaluate the antibacterial properties of methylsulfonylmethane (MSM) on vancomycin-resistant Enterococcus faecium (VRE). Bacterial proliferation was measured spectrophotometrically during growth in brain heart infusion broth with 0%, 3%, 5%, 7%, 10%, 12%, and 16% MSM. To assess the mechanism of inhibition, VRE was grown overnight with 0-16% MSM and enumerated on unmedicated and medicated (3-16% MSM) brain heart infusion agar (BHIA). Viability studies were performed to evaluate the impact of 10-16% MSM on VRE over 7 days. Absorbance data indicated a dose-dependent inhibition from 0% to 7% MSM and no increase in optical density in 10-16% MSM. VRE enumerated on unmedicated BHIA from overnight cultures with 10-16% MSM partially recovered. No growth was observed when BHIA contained 10-16% MSM. There was little effect on VRE growth in 10% MSM over 7 days. VRE displayed a population rebound on day 6 when exposed to 12% MSM, and elimination by day 6 in 16% MSM. Regrowth after MSM removal may be indicative of a bacteriostatic mechanism of inhibition. Cell elimination in 16% MSM suggests inhibition of an essential metabolic function from which the bacterium could not recover.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfonas
/
Dimetil Sulfóxido
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Enterococcus faecium
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Enterococos Resistentes à Vancomicina
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Anti-Inflamatórios
Limite:
Humans
Idioma:
En
Revista:
Microb Drug Resist
Assunto da revista:
MICROBIOLOGIA
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos