Quantifying the Central Dogma in the p53 Pathway in Live Single Cells.

Hafner, Antonina; Reyes, José; Stewart-Ornstein, Jacob; Tsabar, Michael; Jambhekar, Ashwini; Lahav, Galit

Hafner, Antonina; Reyes, José; Stewart-Ornstein, Jacob; Tsabar, Michael; Jambhekar, Ashwini; Lahav, Galit.

Afiliação

Hafner A; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Reyes J; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Stewart-Ornstein J; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Tsabar M; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Jambhekar A; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Lahav G; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: galit@hms.harvard.edu.

Cell Syst ; 10(6): 495-505.e4, 2020 06 24.

Article em En | MEDLINE | ID: mdl-32533938

Assuntos

Fatores de Transcrição/genética; Proteína Supressora de Tumor p53/genética; Humanos

Palavras-chave

MDM inhibition; dynamics; heterogeneity; p21; p53 signaling; single cells; transcription regulation; translation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteína Supressora de Tumor p53 Limite: Humans Idioma: En Revista: Cell Syst Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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