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Near-infrared fluorescent chemodosimeter for real-time in vivo evaluation of H2S-release efficiency of prodrug.
Yao, Xufeng; Liu, Wangwang; Zhu, Wenchao; Tiemuer, Aliya; Zhou, Fangyuan; Yang, Shikui; Yu, Hui; Qian, Xiaoli; Liu, Yi.
Afiliação
  • Yao X; School of Engineering, China Pharmaceutical University, 211198, P. R. China. yiliu@cpu.edu.cn.
  • Liu W; School of Engineering, China Pharmaceutical University, 211198, P. R. China. yiliu@cpu.edu.cn.
  • Zhu W; School of Engineering, China Pharmaceutical University, 211198, P. R. China. yiliu@cpu.edu.cn.
  • Tiemuer A; School of Engineering, China Pharmaceutical University, 211198, P. R. China. yiliu@cpu.edu.cn.
  • Zhou F; School of Engineering, China Pharmaceutical University, 211198, P. R. China. yiliu@cpu.edu.cn.
  • Yang S; School of Engineering, China Pharmaceutical University, 211198, P. R. China. yiliu@cpu.edu.cn.
  • Yu H; School of Engineering, China Pharmaceutical University, 211198, P. R. China. yiliu@cpu.edu.cn.
  • Qian X; School of Engineering, China Pharmaceutical University, 211198, P. R. China. yiliu@cpu.edu.cn.
  • Liu Y; School of Engineering, China Pharmaceutical University, 211198, P. R. China. yiliu@cpu.edu.cn.
Chem Commun (Camb) ; 56(58): 8111-8114, 2020 Jul 21.
Article em En | MEDLINE | ID: mdl-32555858
ABSTRACT
Hydrogen sulfide (H2S) is a significant gasotransmitter. A deficiency in H2S might contribute to some serious diseases. The development of H2S drugs has received a great deal of attention. There is a pressing need for an effective method to evaluate H2S release efficiency, especially in in vivo evaluation. In this study, a highly sensitive and selective near-infrared (NIR) fluorescent chemodosimeter (NRh-N3) was synthesized for detecting H2S. Importantly, NRh-N3 was shown to be capable of visually monitoring H2S-release from the prodrug in vitro and in vivo.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Corantes Fluorescentes / Sulfeto de Hidrogênio Limite: Animals / Humans Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Corantes Fluorescentes / Sulfeto de Hidrogênio Limite: Animals / Humans Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article