The parent drugs chloroquine and hydroxychloroquine do not inhibit human CYP3A activity in vitro.

Li, Xia; Höhl, Rainer; Sörgel, Fritz; Fuhr, Uwe

Li, Xia; Höhl, Rainer; Sörgel, Fritz; Fuhr, Uwe.

Afiliação

Li X; Faculty of Medicine and University Hospital Cologne, Center for Pharmacology, Department I of Pharmacology, University of Cologne, Gleueler Straße 24, 50931, Cologne, Germany.
Höhl R; Institute for Clinical Hygiene, Medical Microbiology and Clinical Infectiology, Paracelsus Medical Private University, Nuremberg Hospital, Nuremberg, Germany.
Sörgel F; IMBP-Institute for Biomedical and Pharmaceutical Research, Nürnberg, Heroldsberg, Germany.
Fuhr U; Institute of Pharmacology, West German Heart and Vascular Centre, University of Duisburg-Essen, Essen, Germany.

Eur J Clin Pharmacol ; 76(10): 1481-1482, 2020 Oct.

Article em En | MEDLINE | ID: mdl-32556540

Assuntos

Cloroquina/farmacologia; Citocromo P-450 CYP3A/efeitos dos fármacos; Hidroxicloroquina/farmacologia; Antirreumáticos/farmacologia; Citocromo P-450 CYP3A/metabolismo; Interações Medicamentosas; Humanos; Técnicas In Vitro

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cloroquina / Citocromo P-450 CYP3A / Hidroxicloroquina Limite: Humans Idioma: En Revista: Eur J Clin Pharmacol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha

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