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Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS.
LaClair, Katherine D; Zhou, Qihui; Michaelsen, Meike; Wefers, Benedikt; Brill, Monika S; Janjic, Aleksandar; Rathkolb, Birgit; Farny, Daniel; Cygan, Mikolaj; de Angelis, Martin Hrabe; Wurst, Wolfgang; Neumann, Manuela; Enard, Wolfgang; Misgeld, Thomas; Arzberger, Thomas; Edbauer, Dieter.
Afiliação
  • LaClair KD; German Center for Neurodegenerative Diseases (DZNE), Munich, 81377, Munich, Germany.
  • Zhou Q; German Center for Neurodegenerative Diseases (DZNE), Munich, 81377, Munich, Germany.
  • Michaelsen M; Munich Cluster for Systems Neurology (SyNergy), 80336, Munich, Germany.
  • Wefers B; German Center for Neurodegenerative Diseases (DZNE), Munich, 81377, Munich, Germany.
  • Brill MS; German Center for Neurodegenerative Diseases (DZNE), Munich, 81377, Munich, Germany.
  • Janjic A; Munich Cluster for Systems Neurology (SyNergy), 80336, Munich, Germany.
  • Rathkolb B; Institute of Neuronal Cell Biology, Technische Universität München, 80802, Munich, Germany.
  • Farny D; Department Biology II, Anthropology and Human Genomics, Ludwig-Maximilians-University Munich, 82152, Martinsried, Germany.
  • Cygan M; German Mouse Clinic, Institute for Experimental Genetics, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany.
  • de Angelis MH; Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-University Munich, 81377, Munich, Germany.
  • Wurst W; German Center for Diabetes Research (DZD), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
  • Neumann M; German Center for Neurodegenerative Diseases (DZNE), Munich, 81377, Munich, Germany.
  • Enard W; German Center for Neurodegenerative Diseases (DZNE), Munich, 81377, Munich, Germany.
  • Misgeld T; German Mouse Clinic, Institute for Experimental Genetics, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany.
  • Arzberger T; German Center for Diabetes Research (DZD), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
  • Edbauer D; Chair of Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, Alte Akademie 8, 85354, Freising, Germany.
Acta Neuropathol ; 140(2): 121-142, 2020 08.
Article em En | MEDLINE | ID: mdl-32562018
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interferons / Proteína C9orf72 / Esclerose Lateral Amiotrófica / Degeneração Neural Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Acta Neuropathol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interferons / Proteína C9orf72 / Esclerose Lateral Amiotrófica / Degeneração Neural Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Acta Neuropathol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha