Proliferation of lymphoid precursor cells in the bone marrow of patients with various disorders of the immune system.
Exp Hematol
; 16(1): 38-41, 1988 Jan.
Article
em En
| MEDLINE
| ID: mdl-3257190
ABSTRACT
In the human bone marrow the nuclear enzyme terminal deoxynucleotidyl transferase (TdT) is expressed by cells during early stages of lymphocyte differentiation. In order to investigate a possible regulation of lymphopoiesis at this level of differentiation, the relative frequency and the in vitro 3H-thymidine labeling index (3HdT-LI) of TdT-positive bone marrow cells were assessed in patients with different functional activities of the immune system. TdT-positive lymphoid precursor cells could be detected in the bone marrow of all children investigated, including six patients with various forms of immunodeficiency. Neither a transient hyperfunction of the immune system during the immunological rebound after cessation of long-term chemotherapy for acute lymphoblastic leukemia, nor a congenital or acquired hypofunction of the immune system had any detectable influence on the invariably high in vitro 3HdT-LI of TdT-positive bone marrow cells, a phenomenon possibly related to an autonomous and high turnover of this precursor cell compartment in the human bone marrow.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medula Óssea
/
Leucemia Linfoide
/
DNA Nucleotidilexotransferase
/
DNA Nucleotidiltransferases
/
Síndromes de Imunodeficiência
Limite:
Adolescent
/
Child
/
Child, preschool
/
Humans
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Infant
/
Middle aged
Idioma:
En
Revista:
Exp Hematol
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Suíça