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Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABAA receptors.
Falk-Petersen, Christina Birkedahl; Tsonkov, Tsonko M; Nielsen, Malene Sofie; Harpsøe, Kasper; Bundgaard, Christoffer; Frølund, Bente; Kristiansen, Uffe; Gloriam, David E; Wellendorph, Petrine.
Afiliação
  • Falk-Petersen CB; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark.
  • Tsonkov TM; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark.
  • Nielsen MS; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark.
  • Harpsøe K; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark.
  • Bundgaard C; Translational DMPK, H. Lundbeck A/S, Ottiliavej 9, 2500, Valby, Denmark.
  • Frølund B; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark.
  • Kristiansen U; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark.
  • Gloriam DE; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark.
  • Wellendorph P; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark. pw@sund.ku.dk.
Sci Rep ; 10(1): 10078, 2020 06 22.
Article em En | MEDLINE | ID: mdl-32572053
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de GABA-A / Antagonistas de Receptores de GABA-A Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Dinamarca
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de GABA-A / Antagonistas de Receptores de GABA-A Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Dinamarca