Asymmetric copper-catalyzed fluorination of cyclic ß-keto esters in a continuous-flow microreactor.

Wang, Yi-Feng; Jiang, Zhen-Hui; Chu, Ming-Ming; Qi, Suo-Suo; Yin, Hao; Han, Hong-Te; Xu, Dan-Qian

Wang, Yi-Feng; Jiang, Zhen-Hui; Chu, Ming-Ming; Qi, Suo-Suo; Yin, Hao; Han, Hong-Te; Xu, Dan-Qian.

Afiliação

Wang YF; State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Key Laboratory of Green Pesticides and Cleaner Production Technology of Zhejiang Province, Department of Green Chemistry and Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China. wangyifeng@zjut.edu.cn
Jiang ZH; State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Key Laboratory of Green Pesticides and Cleaner Production Technology of Zhejiang Province, Department of Green Chemistry and Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China. wangyifeng@zjut.edu.cn
Chu MM; State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Key Laboratory of Green Pesticides and Cleaner Production Technology of Zhejiang Province, Department of Green Chemistry and Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China. wangyifeng@zjut.edu.cn
Qi SS; State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Key Laboratory of Green Pesticides and Cleaner Production Technology of Zhejiang Province, Department of Green Chemistry and Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China. wangyifeng@zjut.edu.cn
Yin H; State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Key Laboratory of Green Pesticides and Cleaner Production Technology of Zhejiang Province, Department of Green Chemistry and Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China. wangyifeng@zjut.edu.cn
Han HT; State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Key Laboratory of Green Pesticides and Cleaner Production Technology of Zhejiang Province, Department of Green Chemistry and Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China. wangyifeng@zjut.edu.cn
Xu DQ; State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Key Laboratory of Green Pesticides and Cleaner Production Technology of Zhejiang Province, Department of Green Chemistry and Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China. wangyifeng@zjut.edu.cn

Org Biomol Chem ; 18(26): 4927-4931, 2020 07 08.

Article em En | MEDLINE | ID: mdl-32573633

ABSTRACT

ABSTRACT

A highly enantioselective homogeneous fluorination of cyclic ß-keto esters catalyzed by diphenylamine linked bis(oxazoline)-Cu(OTf)2 complexes has been established in a continuous flow microreactor. The microreactor allowed an efficient transformation with reaction times ranging from 0.5 to 20 min, and the desired products were afforded in high yields (up to 99%) with excellent enantioselectivities (up to 99% ee) at a low catalyst loading of 1 mol%.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article

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