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Chromobox 2 Expression Predicts Prognosis After Curative Resection of Oesophageal Squamous Cell Carcinoma.
Ueda, Sei; Kanda, Mitsuro; Sato, Yusuke; Baba, Hayato; Nakamura, Shunsuke; Sawaki, Koichi; Shimizu, Dai; Motoyama, Satoru; Fujii, Tsutomu; Kodera, Yasuhiro; Nomoto, Shuji.
Afiliação
  • Ueda S; Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Kanda M; Department of Maxillofacial Surgery, School of Dentistry, Aichi-gakuin University Graduate School of Medicine, Nagoya, Japan.
  • Sato Y; Department of Surgery, School of Dentistry, Aichi-gakuin University Graduate School of Medicine, Nagoya, Japan.
  • Baba H; Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan m-kanda@med.nagoya-u.ac.jp.
  • Nakamura S; Department of Thoracic Surgery, Akita University Graduate School of Medicine, Akita, Japan.
  • Sawaki K; Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Shimizu D; Department of Surgery and Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
  • Motoyama S; Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Fujii T; Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Kodera Y; Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Nomoto S; Department of Thoracic Surgery, Akita University Graduate School of Medicine, Akita, Japan.
Cancer Genomics Proteomics ; 17(4): 391-400, 2020.
Article em En | MEDLINE | ID: mdl-32576584
ABSTRACT
BACKGROUND/

AIM:

To investigate the function of chromobox 2 (CBX2) in oesophageal squamous cell carcinoma (OSCC). MATERIALS AND

METHODS:

We used real-time quantitative reverse transcription PCR (qRT-PCR) and immunohistochemistry to determine CBX2 expression levels in 13 human OSCC cell lines and clinical specimens of two independent cohorts of patients with OSCC.

RESULTS:

PCR array analysis revealed that CBX2 was co-ordinately expressed with WNT5B in OSCC cell lines. RT-qPCR analysis of clinical samples revealed a high tumour-specific CBX2 expression compared with normal oesophageal tissues. High CBX2 expression was significantly associated with shorter disease-specific survival, hematogenous recurrence, and overall recurrence. Analysis of tissue microarrays of one cohort revealed that patients with higher CBX2 levels tended to have a shorter disease-specific survival.

CONCLUSION:

CBX2 overexpression in OSCC tissues may serve as a novel biomarker for predicting survival and hematogenous recurrence.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Biomarcadores Tumorais / Esofagectomia / Complexo Repressor Polycomb 1 / Carcinoma de Células Escamosas do Esôfago / Recidiva Local de Neoplasia Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En Revista: Cancer Genomics Proteomics Assunto da revista: BIOQUIMICA / GENETICA MEDICA / NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Biomarcadores Tumorais / Esofagectomia / Complexo Repressor Polycomb 1 / Carcinoma de Células Escamosas do Esôfago / Recidiva Local de Neoplasia Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En Revista: Cancer Genomics Proteomics Assunto da revista: BIOQUIMICA / GENETICA MEDICA / NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão