Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells.

Garribba, Lorenza; Bjerregaard, Victoria A; Gonçalves Dinis, Marisa M; Özer, Özgün; Wu, Wei; Sakellariou, Despoina; Pena-Diaz, Javier; Hickson, Ian D; Liu, Ying

Garribba, Lorenza; Bjerregaard, Victoria A; Gonçalves Dinis, Marisa M; Özer, Özgün; Wu, Wei; Sakellariou, Despoina; Pena-Diaz, Javier; Hickson, Ian D; Liu, Ying.

Afiliação

Garribba L; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.
Bjerregaard VA; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.
Gonçalves Dinis MM; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.
Özer Ö; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.
Wu W; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.
Sakellariou D; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.
Pena-Diaz J; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.
Hickson ID; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.
Liu Y; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.

Proc Natl Acad Sci U S A ; 117(28): 16527-16536, 2020 07 14.

Article em En | MEDLINE | ID: mdl-32601218

Assuntos

Endodesoxirribonucleases/metabolismo; Ácido Fólico/metabolismo; Síndrome do Cromossomo X Frágil/metabolismo; Mitose; Rad51 Recombinase/metabolismo; DNA/genética; DNA/metabolismo; Reparo do DNA; Endodesoxirribonucleases/genética; Síndrome do Cromossomo X Frágil/genética; Síndrome do Cromossomo X Frágil/fisiopatologia; Humanos; Rad51 Recombinase/genética; Proteína Rad52 de Recombinação e Reparo de DNA/genética; Proteína Rad52 de Recombinação e Reparo de DNA/metabolismo; Recombinases/genética; Recombinases/metabolismo

Palavras-chave

MiDAS; break-induced DNA replication (BIR); chromosome fragile sites; homologous recombination; structure-specific endonucleases

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endodesoxirribonucleases / Rad51 Recombinase / Ácido Fólico / Síndrome do Cromossomo X Frágil / Mitose Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Dinamarca

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