Neurotoxicity Despite a Renal Function-Adjusted Cefepime Regimen: A Case Study.
Ther Drug Monit
; 42(5): 655-657, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-32618881
ABSTRACT
An 83-year-old man, presenting decreased renal function (estimated glomerular filtration rate 21 mL/min/1.73 m), was treated for a bone and joint infection (on a trans-metatarsal right foot amputation) caused by Klebsiella Pneumonia sensitive to cefepime. The starting dose (1 g bid) was based on recommendations for patients presenting severe infections. One week after treatment initiation, the patient developed neurotoxicity, exhibiting extremely high plasma cefepime concentrations. Based on TDM, the dose was reduced by 8 times the original dose. This case report highlights the importance of therapeutic drug monitoring for cefepime, especially in patients presenting altered renal functions, as typical recommendations are estimated for standard patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndromes Neurotóxicas
/
Cefepima
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Rim
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Antibacterianos
Tipo de estudo:
Guideline
Limite:
Aged80
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Humans
/
Male
Idioma:
En
Revista:
Ther Drug Monit
Ano de publicação:
2020
Tipo de documento:
Article