Is CpG Density the Link between Epigenetic Aging and Lifespan?

Bertucci, Emily M; Parrott, Benjamin B

Bertucci, Emily M; Parrott, Benjamin B.

Afiliação

Bertucci EM; Savannah River Ecology Laboratory, Aiken, SC 29802, USA; Eugene P. Odum School of Ecology, University of Georgia, Athens, GA 30602, USA.
Parrott BB; Savannah River Ecology Laboratory, Aiken, SC 29802, USA; Eugene P. Odum School of Ecology, University of Georgia, Athens, GA 30602, USA. Electronic address: benparrott@srel.uga.edu.

Trends Genet ; 36(10): 725-727, 2020 10.

Article em En | MEDLINE | ID: mdl-32624337

RESUMO

The genetic mechanisms contributing to lifespan variation remain unresolved. Based on recent conceptual advances in our understanding of epigenetic potential and the relocalization of chromatin modifiers (RCM), we hypothesize that increased CpG density is protective against age-related erosion of the epigenetic landscape and may explain interspecific variation in lifespan.

Assuntos

Envelhecimento/genética; Ilhas de CpG; Metilação de DNA; Longevidade/genética; Animais; Epigênese Genética; Humanos

Palavras-chave

DNA methylation; epigenetic aging; epigenetic potential; lifespan

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Ilhas de CpG / Metilação de DNA / Longevidade Limite: Animals / Humans Idioma: En Revista: Trends Genet Assunto da revista: GENETICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google