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New prenylflavonol glycosides with xanthine oxidase inhibitory activity from the leaves of Cyclocarya paliurus.
Ye, Zi-Jun; He, Xiao-Ai; Wu, Jian-Ping; Li, Jing; Chang, Xi-Wen; Tan, Jie; Lv, Wen-Yan; Zhu, Hui; Sun, Hui-Hui; Wang, Wen-Xuan; Chen, Zu-Hui; Zhu, Gang-Zhi; Xu, Kang-Ping.
Afiliação
  • Ye ZJ; Department of Pharmacy, Affiliated HaiKou Hospital Xiangya School of Medicine, Central South University, Haikou 570100, PR China.
  • He XA; Department of Pharmacy, Affiliated HaiKou Hospital Xiangya School of Medicine, Central South University, Haikou 570100, PR China.
  • Wu JP; Department of Pharmacochemistry, College of Xiangya Pharmacy, Central South University, Changsha 410013, PR China.
  • Li J; Department of Pharmacochemistry, College of Xiangya Pharmacy, Central South University, Changsha 410013, PR China.
  • Chang XW; Department of Pharmacochemistry, College of Xiangya Pharmacy, Central South University, Changsha 410013, PR China.
  • Tan J; Department of Pharmacochemistry, College of Xiangya Pharmacy, Central South University, Changsha 410013, PR China.
  • Lv WY; Department of Pharmacochemistry, College of Xiangya Pharmacy, Central South University, Changsha 410013, PR China.
  • Zhu H; Department of Pharmacochemistry, College of Xiangya Pharmacy, Central South University, Changsha 410013, PR China.
  • Sun HH; Department of Pharmacochemistry, College of Xiangya Pharmacy, Central South University, Changsha 410013, PR China.
  • Wang WX; Department of Pharmacochemistry, College of Xiangya Pharmacy, Central South University, Changsha 410013, PR China.
  • Chen ZH; Department of Pharmacochemistry, College of Xiangya Pharmacy, Central South University, Changsha 410013, PR China; Hunan Heran Biotechnology Development Company, 410013 Changsha, PR China.
  • Zhu GZ; Department of Pharmacy, Affiliated HaiKou Hospital Xiangya School of Medicine, Central South University, Haikou 570100, PR China.
  • Xu KP; Department of Pharmacochemistry, College of Xiangya Pharmacy, Central South University, Changsha 410013, PR China. Electronic address: xukp395@csu.edu.cn.
Bioorg Chem ; 101: 104018, 2020 08.
Article em En | MEDLINE | ID: mdl-32629277
ABSTRACT
Eight new prenylflavonol glycosides (1-8), along with five known analogues (9-13) were isolated from the n-butanol extract of the dried leaves of Cyclocarya paliurus (family Juglandaceae) for the first time. The structures of these compounds were characterized by comprehensive analysis of 1D, 2D NMR, HRESIMS, UV data and acid hydrolysis. In bioassay, all these thirteen prenylflavonol glycosides exhibited inhibitory effects on xanthine oxidase (XOD) activity. Especially compounds 2 and 7, showed outstanding IC50 values of 31.81 ± 2.20 and 29.71 ± 3.69 µM, respectively.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Xantina Oxidase / Folhas de Planta / Juglandaceae / Flavonóis / Inibidores Enzimáticos / Glicosídeos Idioma: En Revista: Bioorg Chem Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Xantina Oxidase / Folhas de Planta / Juglandaceae / Flavonóis / Inibidores Enzimáticos / Glicosídeos Idioma: En Revista: Bioorg Chem Ano de publicação: 2020 Tipo de documento: Article