Comprehensive analysis of multiple parameters associated with tumor immune microenvironment in ARID1A mutant cancers.
Future Oncol
; 16(29): 2295-2306, 2020 Oct.
Article
em En
| MEDLINE
| ID: mdl-32639175
ABSTRACT
Aim:
To verify the relationship between ARID1A and tumor immune microenvironment thus immune checkpoint inhibitors (ICIs) response. Material &methods:
Several public databases were used to characterize the association between ARID1A gene alteration and tumor immunity.Results:
The gene mutation frequency was 8.2% in all cancer types. The ARID1A-mutated cancers have higher scores of mutation count, tumor mutational burden, neoantigen load (p < 0.001) and T cell repertoire, B cell repertoire diversity (p < 0.05). The gene mutation has tight association with multiple-activated immune cells. Survival analysis suggested that patients with ARID1A mutant cancers benefit more from ICIs treatment (p = 0.013).Conclusion:
The ARID1A gene mutation was correlated with higher tumor immunogenicity and activated antitumor immune microenvironment, resulting in superior cohort that respond well to ICIs.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Biomarcadores Tumorais
/
Proteínas de Ligação a DNA
/
Microambiente Tumoral
/
Mutação
/
Neoplasias
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Future Oncol
Ano de publicação:
2020
Tipo de documento:
Article