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Highly oxygenated angucycline from Streptomyces sp. KCB15JA014.
Kim, Gil Soo; Kim, Geum Jin; Lee, Byeongsan; Oh, Tae Hoon; Kwon, Mincheol; Lee, Jung-Sook; Jang, Jun-Pil; Choi, Hyukjae; Ko, Sung-Kyun; Hong, Young-Soo; Jang, Jae-Hyuk; Ahn, Jong Seog.
Afiliação
  • Kim GS; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28116, Korea.
  • Kim GJ; Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, 34113, Korea.
  • Lee B; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Korea.
  • Oh TH; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28116, Korea.
  • Kwon M; College of Pharmacy, Chungbuk National University, Cheongju, 28160, Korea.
  • Lee JS; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28116, Korea.
  • Jang JP; College of Pharmacy, Chungbuk National University, Cheongju, 28160, Korea.
  • Choi H; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28116, Korea.
  • Ko SK; Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, 34113, Korea.
  • Hong YS; Korean Collection for Type Cultures, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, 56212, Korea.
  • Jang JH; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28116, Korea.
  • Ahn JS; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Korea.
J Antibiot (Tokyo) ; 73(12): 859-862, 2020 12.
Article em En | MEDLINE | ID: mdl-32647213
LC/MS-based chemical screening of culture extract led to a new highly oxygenated angucycline derivative, grecocycline D (1), from Streptomyces sp. KCB15JA014, isolated from a soil sample of Oedolgae in Jeju Island, Korea. The planar structure was determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as HRESIMS and comparison with data from the literature. A relative and absolute configuration of 1 was assigned by ROESY experiment and electronic circular dichroism calculation. Compound 1 showed weak inhibitory activity against indoleamine 2,3-dioxygenase.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Streptomyces / Antraquinonas / Citotoxinas Limite: Animals Idioma: En Revista: J Antibiot (Tokyo) Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Streptomyces / Antraquinonas / Citotoxinas Limite: Animals Idioma: En Revista: J Antibiot (Tokyo) Ano de publicação: 2020 Tipo de documento: Article