Investigating the utility of extended mutation analysis in gastrointestinal peritoneal metastasis.
J Surg Oncol
; 122(6): 1106-1113, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-32662065
ABSTRACT
BACKGROUND AND OBJECTIVES:
Outcomes for gastrointestinal peritoneal metastases (GI-PM) are worse compared to systemic metastases, with a paucity of data exploring extended mutation profiling. An exploratory mutation analysis in GI-PMs was performed as a "proof of concept" of potential predictive values of profiling in GI-PM and rates of actionable mutations.METHODS:
The study included 40 GI-PM patients 14 low-grade mucinous carcinoma peritonei and 26 HG-PM (12 colons, 10 appendix, 4 small bowels). Demographics, histologies, peritoneal cancer indexes, cytoreduction scores, and survival data were collected. NGS 50-gene mutation profiling was performed on 38 specimens. The association of mutations with survival was evaluated in high-grade PM.RESULTS:
KRAS, TP53, and SMAD4 mutations were observed in 61%, 29%, and 8% of cases across all tumor histologies. In 66% cases >1 mutations occurred, associated with decreased survival in HG-PM 32 vs 73 months, P = .03. TP53 or SMAD4 mutations were associated with decreased survival in HG-PM 22 vs 48 months, P = .02. Actionable mutations were detected in 70%.CONCLUSION:
Actionable mutations were detected at high rates. GI-PMs have similar mutational profiles and TP53, SMAD4, and/or >1 mutation were associate with decreased survival in HG-PM. This data supports the concept of the extended mutation profiling utility in GI-PM warranting further investigation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Peritoneais
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Análise Mutacional de DNA
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Biomarcadores Tumorais
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Adenocarcinoma Mucinoso
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Procedimentos Cirúrgicos de Citorredução
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Neoplasias Gastrointestinais
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Mutação
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Surg Oncol
Ano de publicação:
2020
Tipo de documento:
Article