Manganese increases Aß and Tau protein levels through proteasome 20S and heat shock proteins 90 and 70 alteration, leading to SN56 cholinergic cell death following single and repeated treatment.

Moyano, Paula; García, José Manuel; García, Jimena; Anadon, María José; Naval, María Victoria; Frejo, María Teresa; Sola, Emma; Pelayo, Adela; Pino, Javier Del

Moyano, Paula; García, José Manuel; García, Jimena; Anadon, María José; Naval, María Victoria; Frejo, María Teresa; Sola, Emma; Pelayo, Adela; Pino, Javier Del.

Afiliação

Moyano P; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
García JM; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
García J; Department of Pharmacolgy, Health Sciences School, Alfonso X University, 28691, Madrid, Spain.
Anadon MJ; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Naval MV; Department of Pharmacology, Pharmacognosy and Botany, Pharmacy School, Complutense University of Madrid, 28040, Madrid, Spain.
Frejo MT; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain.
Sola E; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Pelayo A; Department of Legal Medicine, Psychiatry and Pathology, Medicine School, Complutense University of Madrid, 28041, Madrid, Spain.
Pino JD; Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address: jdelpino@pdi.ucm.es.

Ecotoxicol Environ Saf ; 203: 110975, 2020 Oct 15.

Article em En | MEDLINE | ID: mdl-32678756

Assuntos

Peptídeos beta-Amiloides/metabolismo; Prosencéfalo Basal/efeitos dos fármacos; Neurônios Colinérgicos/efeitos dos fármacos; Poluentes Ambientais/toxicidade; Proteínas de Choque Térmico HSP70/metabolismo; Proteínas de Choque Térmico HSP90/metabolismo; Manganês/toxicidade; Complexo de Endopeptidases do Proteassoma/metabolismo; Proteínas tau/metabolismo; Animais; Prosencéfalo Basal/metabolismo; Prosencéfalo Basal/patologia; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Neurônios Colinérgicos/metabolismo; Neurônios Colinérgicos/patologia; Relação Dose-Resposta a Droga; Poluentes Ambientais/metabolismo; Manganês/metabolismo; Camundongos; Estresse Oxidativo/efeitos dos fármacos

Palavras-chave

And pTau proteins; Aß; Heat shock proteins; Manganese; NRF2; P20S; SN56 basal forebrain cholinergic neurons

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Proteínas tau / Proteínas de Choque Térmico HSP90 / Proteínas de Choque Térmico HSP70 / Complexo de Endopeptidases do Proteassoma / Poluentes Ambientais / Neurônios Colinérgicos / Prosencéfalo Basal / Manganês Limite: Animals Idioma: En Revista: Ecotoxicol Environ Saf Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha

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