Aberrantly elevated suprabasin in the bone marrow as a candidate biomarker of advanced disease state in myelodysplastic syndromes.

Pribyl, Miroslav; Hubackova, Sona; Moudra, Alena; Vancurova, Marketa; Polackova, Helena; Stopka, Tomas; Jonasova, Anna; Bokorova, Radka; Fuchs, Ota; Stritesky, Jan; Salovska, Barbora; Bartek, Jiri; Hodny, Zdenek

Pribyl, Miroslav; Hubackova, Sona; Moudra, Alena; Vancurova, Marketa; Polackova, Helena; Stopka, Tomas; Jonasova, Anna; Bokorova, Radka; Fuchs, Ota; Stritesky, Jan; Salovska, Barbora; Bartek, Jiri; Hodny, Zdenek.

Afiliação

Pribyl M; Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Hubackova S; Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Moudra A; Molecular Therapy of Cancer Group, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prague, Czech Republic.
Vancurova M; Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Polackova H; Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Stopka T; 1st Department of Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic.
Jonasova A; 1st Department of Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic.
Bokorova R; Group of Mechanisms Involved in Remodeling of Chromatin Structure During Cell Fate Decisions, BIOCEV, Prague, Czech Republic.
Fuchs O; 1st Department of Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic.
Stritesky J; Department of Genomics, Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
Salovska B; Department of Genomics, Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
Bartek J; Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
Hodny Z; Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.

Mol Oncol ; 14(10): 2403-2419, 2020 10.

Article em En | MEDLINE | ID: mdl-32696549

Assuntos

Antígenos de Diferenciação/metabolismo; Medula Óssea/metabolismo; Síndromes Mielodisplásicas/metabolismo; Proteínas de Neoplasias/metabolismo; Antígenos de Diferenciação/sangue; Antígenos de Diferenciação/genética; Azacitidina/farmacologia; Biomarcadores/sangue; Biomarcadores/metabolismo; Compartimento Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Quimiocina CCL2/metabolismo; Regulação Neoplásica da Expressão Gênica; Células HEK293; Humanos; Interferon gama/farmacologia; Leucócitos Mononucleares/metabolismo; Contagem de Linfócitos; Síndromes Mielodisplásicas/sangue; Células Mieloides/efeitos dos fármacos; Células Mieloides/metabolismo; Proteínas de Neoplasias/sangue; Proteínas de Neoplasias/genética; Prognóstico; Proto-Oncogene Mas; RNA Mensageiro/genética; RNA Mensageiro/metabolismo

Palavras-chave

5-azacytidine; MDS; MDSCs; biomarker; suprabasin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medula Óssea / Síndromes Mielodisplásicas / Antígenos de Diferenciação / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Mol Oncol Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: República Tcheca

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