Translation of in vitro cannabinoid 1 receptor agonist activity to in vivo pharmacodynamic endpoints.

Jenkinson, Stephen; Goody, Susan M G; Bassyouni, Asser; Jones, Rhys; Otto-Bruc, Annie; Duquennoy, Stephanie; DaSilva, Jamie K; Butler, Paul; Mead, Andy

Jenkinson, Stephen; Goody, Susan M G; Bassyouni, Asser; Jones, Rhys; Otto-Bruc, Annie; Duquennoy, Stephanie; DaSilva, Jamie K; Butler, Paul; Mead, Andy.

Afiliação

Jenkinson S; Worldwide Research and Development, Pfizer Inc., La Jolla, CA 92121, USA. Electronic address: stephen.jenkinson@pfizer.com.
Goody SMG; Worldwide Research and Development, Pfizer Inc., Groton, CT 06340, USA.
Bassyouni A; Worldwide Research and Development, Pfizer Inc., La Jolla, CA 92121, USA.
Jones R; Worldwide Research and Development, Pfizer Inc., La Jolla, CA 92121, USA.
Otto-Bruc A; Eurofins CEREP SA, Celle-Levescault, France.
Duquennoy S; Eurofins CEREP SA, Celle-Levescault, France.
DaSilva JK; Worldwide Research and Development, Pfizer Inc., Groton, CT 06340, USA.
Butler P; Worldwide Research and Development, Pfizer Inc., La Jolla, CA 92121, USA.
Mead A; Worldwide Research and Development, Pfizer Inc., Groton, CT 06340, USA.

J Pharmacol Toxicol Methods ; 104: 106899, 2020.

Article em En | MEDLINE | ID: mdl-32702414

Assuntos

Agonistas de Receptores de Canabinoides/farmacologia; AMP Cíclico/metabolismo; Receptor CB1 de Canabinoide/agonistas; beta-Arrestinas/metabolismo; Animais; Células CHO; Linhagem Celular; Cricetulus; Descoberta de Drogas/métodos; Humanos; Masculino; Ratos; Receptor CB1 de Canabinoide/metabolismo; Pesquisa Translacional Biomédica

Palavras-chave

Agonism; Cannabinoid receptor 1; Drug discrimination; In vitro; In vivo; Tetrad; Translation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: AMP Cíclico / Receptor CB1 de Canabinoide / Agonistas de Receptores de Canabinoides / Beta-Arrestinas Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: J Pharmacol Toxicol Methods Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2020 Tipo de documento: Article

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