Cation channel conductance and pH gating of the innate immunity factor APOL1 are governed by pore-lining residues within the C-terminal domain.

Schaub, Charles; Verdi, Joseph; Lee, Penny; Terra, Nada; Limon, Gina; Raper, Jayne; Thomson, Russell

Schaub, Charles; Verdi, Joseph; Lee, Penny; Terra, Nada; Limon, Gina; Raper, Jayne; Thomson, Russell.

Afiliação

Schaub C; Department of Biological Sciences, Hunter College, CUNY, New York, USA; Program in Biochemistry, The Graduate Center, CUNY, New York, USA.
Verdi J; Department of Biological Sciences, Hunter College, CUNY, New York, USA; Program in Biology, The Graduate Center, CUNY, New York, USA; German Cancer Research Center, Heidelberg, Germany.
Lee P; Department of Biological Sciences, Hunter College, CUNY, New York, USA.
Terra N; Department of Biological Sciences, Hunter College, CUNY, New York, USA.
Limon G; Department of Biological Sciences, Hunter College, CUNY, New York, USA; NYU School of Medicine, New York, USA.
Raper J; Department of Biological Sciences, Hunter College, CUNY, New York, USA.
Thomson R; Department of Biological Sciences, Hunter College, CUNY, New York, USA. Electronic address: rthomson@genectr.hunter.cuny.edu.

J Biol Chem ; 295(38): 13138-13149, 2020 09 18.

Article em En | MEDLINE | ID: mdl-32727852

Assuntos

Apolipoproteína L1/química; Imunidade Inata; Animais; Apolipoproteína L1/genética; Apolipoproteína L1/imunologia; Sequências Hélice-Alça-Hélice; Humanos; Concentração de Íons de Hidrogênio; Papio hamadryas; Trypanosoma brucei brucei/imunologia

Palavras-chave

APOL1; APOL1-associated nephropathy; Trypanosoma brucei; apolipoprotein; cytolysis; electrophysiology; focal-segmental glomerulosclerosis (FSGS); glomerulosclerosis; high-density lipoprotein (HDL); human African trypanosomiasis (HAT); innate immunity; ion channel; kidney; kidney disease; lipid bilayer; lipoprotein; nonselective cation channel; pH-dependent membrane insertion; pH-gated cation channel; planar lipid bilayers; trypanosome lytic factor (TLF)

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apolipoproteína L1 / Imunidade Inata Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google