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TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.
Hegde, Ramanath Narayana; Chiki, Anass; Petricca, Lara; Martufi, Paola; Arbez, Nicolas; Mouchiroud, Laurent; Auwerx, Johan; Landles, Christian; Bates, Gillian P; Singh-Bains, Malvindar K; Dragunow, Mike; Curtis, Maurice A; Faull, Richard Lm; Ross, Christopher A; Caricasole, Andrea; Lashuel, Hilal A.
Afiliação
  • Hegde RN; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
  • Chiki A; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
  • Petricca L; Department of Neuroscience, IRBM Science Park, Rome, Italy.
  • Martufi P; Department of Neuroscience, IRBM Science Park, Rome, Italy.
  • Arbez N; Division of Neurobiology, Department of Psychiatry and Departments of Neurology, Neuroscience and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Mouchiroud L; Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
  • Auwerx J; Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
  • Landles C; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London, UK.
  • Bates GP; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London, UK.
  • Singh-Bains MK; Centre for Brain Research, Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.
  • Dragunow M; Centre for Brain Research, Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand.
  • Curtis MA; Centre for Brain Research, Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.
  • Faull RL; Centre for Brain Research, Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.
  • Ross CA; Division of Neurobiology, Department of Psychiatry and Departments of Neurology, Neuroscience and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Caricasole A; Department of Neuroscience, IRBM Science Park, Rome, Italy.
  • Lashuel HA; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
EMBO J ; 39(17): e104671, 2020 09 01.
Article em En | MEDLINE | ID: mdl-32757223
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Caenorhabditis elegans / Doença de Huntington / Agregados Proteicos / Proteína Huntingtina / Mutação Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: EMBO J Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suíça
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Caenorhabditis elegans / Doença de Huntington / Agregados Proteicos / Proteína Huntingtina / Mutação Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: EMBO J Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suíça