Electrophysiological features and prognosis of Guillain-Barré syndrome in Israel: A single-center's 20 years' experience.
J Neurol Sci
; 417: 117074, 2020 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-32768719
ABSTRACT
INTRODUCTION:
We previously reported on 40 patients with Guillain-Barré syndrome (GBS) identified 1999-2005 at our center, and showed that a higher proportion had an axonal pattern, compared to Europe and North America.METHODS:
Retrospective chart review of 100 adult patients with GBS between 2006 and 2018 at Shamir Medical Center.RESULTS:
46.8% of those with an abnormal EMG had an axonal pattern. Of the 60 patients who presented with mild disease (defined as Hughes score 1-2), walking deteriorated in 35 (58%, considering any worsening of Hughes score). 20 patients (33%) lost the ability to walk independently (Hughes score 3), 8 reached a point they could not walk (Hughes 4), and 2 needed mechanical ventilation. Ninety-four of 100 patients (94%) were treated with intravenous immunoglobulins (IVIg). Using ECG monitoring and DVT prophylaxis, IVIg-related adverse reactions were rare.CONCLUSIONS:
This study demonstrated a higher proportion of axonal GBS patients in Israel, compared to European and North American patients, replicating the findings in the 1999-2005 patients. Due to the progressive nature of the disease, with more than half of patients presenting with mild disease deteriorating and needing inpatient rehabilitation - we advocate initiation of treatment once a clinical diagnosis of GBS is made.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Guillain-Barré
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
País/Região como assunto:
America do norte
/
Asia
/
Europa
Idioma:
En
Revista:
J Neurol Sci
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Israel