Evolution of SIVsm in humanized mice towards HIV-2.

Curlin, James; Schmitt, Kimberly; Remling-Mulder, Leila; Moriarty, Ryan; Goff, Kelly; O'Connor, Shelby; Stenglein, Mark; Marx, Preston; Akkina, Ramesh

Curlin, James; Schmitt, Kimberly; Remling-Mulder, Leila; Moriarty, Ryan; Goff, Kelly; O'Connor, Shelby; Stenglein, Mark; Marx, Preston; Akkina, Ramesh.

Afiliação

Curlin J; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Schmitt K; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Remling-Mulder L; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Moriarty R; University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Goff K; Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
O'Connor S; University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Stenglein M; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Marx P; Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Akkina R; Tulane National Primate Research Center, Covington, LA, USA.

J Med Primatol ; 49(5): 280-283, 2020 10.

Article em En | MEDLINE | ID: mdl-32777101

RESUMO

Through the accumulation of adaptive mutations, HIV-2 originated from SIVsm. To identify these evolutionary changes, a humanized mouse model recapitulated the process that likely enabled this cross-species transmission event. Various adaptive mutations arose, as well as increased virulence and CD4+ T-cell decline as the virus was passaged in humanized mice.

Assuntos

Contagem de Linfócito CD4; Evolução Molecular; HIV-2/genética; HIV-2/patogenicidade; Vírus da Imunodeficiência Símia/genética; Vírus da Imunodeficiência Símia/patogenicidade; Animais; Cercocebus atys; Modelos Animais de Doenças; Camundongos; Camundongos Transgênicos; Doenças dos Macacos; Mutação; Virulência

Palavras-chave

HIV-2 viral evolution; SIVsm evolution towards HIV-2; SIVsm infection in humanized mice; Sooty Mangabeys; cross-species SIV transmission; hu-HSC mice for viral cross-species jump

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: HIV-2 / Vírus da Imunodeficiência Símia / Contagem de Linfócito CD4 / Evolução Molecular Limite: Animals Idioma: En Revista: J Med Primatol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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