Ambroxol and Ciprofloxacin Show Activity Against SARS-CoV2 in Vero E6 Cells at Clinically-Relevant Concentrations.

Bradfute, Steven B; Ye, Chunyan; Clarke, Elizabeth C; Kumar, Suresh; Timmins, Graham S; Deretic, Vojo

Bradfute, Steven B; Ye, Chunyan; Clarke, Elizabeth C; Kumar, Suresh; Timmins, Graham S; Deretic, Vojo.

Afiliação

Bradfute SB; Center for Global Health, Department of Internal Medicine, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Ye C; Center for Global Health, Department of Internal Medicine, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Clarke EC; Center for Global Health, Department of Internal Medicine, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Kumar S; Autophagy, Inflammation and Metabolism (AIM) Center, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Timmins GS; Department of Microbiology and Molecular Genetics, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Deretic V; Autophagy, Inflammation and Metabolism (AIM) Center, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

bioRxiv ; 2020 Aug 11.

Article em En | MEDLINE | ID: mdl-32817934

ABSTRACT

ABSTRACT

We studied the activity of a range of weakly basic and moderately lipophilic drugs against SARS CoV2 in Vero E6 cells, using Vero E6 survival, qPCR of viral genome and plaque forming assays. No clear relationship between their weakly basic and hydrophobic nature upon their activity was observed. However, the approved drugs ambroxol and ciprofloxacin showed potent activity at concentrations that are clinically relevant and within their known safety profiles, and so may provide potentially useful agents for preclinical and clinical studies in COVID-19.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: BioRxiv Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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