Prognostic Role of High Sensitivity Troponin T (hsTnT) After Recanalization of Chronic Total Occlusions (CTO).
Cardiovasc Revasc Med
; 29: 89-92, 2021 08.
Article
em En
| MEDLINE
| ID: mdl-32847727
ABSTRACT
BACKGROUND:
The prognostic role of periprocedural hsTnT after percutaneous coronary intervention (PCI) of CTOs is unknown. We evaluated the incidence and impact of hsTnT elevations on clinical and angiographic outcomes after CTO-PCI.METHODS:
In a retrospective database analysis we identified 309 successfully treated CTO-PCI patients that had a re-angiography 6 months after the initial procedure. Both catheterizations were used for quantitative coronary angiography (QCA). HsTnT was measured before and 18-24 h after CTO-PCI. According to periinterventional hsTnT release patients were divided into 4 quartiles (QI 0-99 ng/l; QII 100-199 ng/l; QIII 200-299 ng/l; QIV ≥300 ng/l) and correlated with QCA and clinical data.RESULTS:
Mean age of the patient population was 67 ± 10.6 years. The antegrade approach was used in 91% of the procedures. After treatment, in-CTO-segment minimal lumen diameter (MLD) was 2.97 ± 0.42 mm. On 6 months follow up In-CTO-segment MLD decreased to 2.74 ± 0.71 mm which corresponded to an In-CTO-segment late lumen loss (LLL) of 0.23 ± 0.45 mm. Target lesion revascularization rate (TLR) occurred in 21 of 309 patients (6.8%). Higher periinterventional hsTnT release (QIII-IV) was associated with more frequent TLR compared to lower hsTnT release (QI-II) (28.6% vs. 4%; p < 0.0001). In a multivariable model hsTnT release emerged as an independent predictor of TLR (OR 7.3; 95%CI 2.12-26.9).CONCLUSIONS:
Our findings suggest that hsTnT release is associated with increased TLR. Therefore, peri-interventional hsTnT measurement might be useful in the risk stratification of CTO procedures.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oclusão Coronária
/
Intervenção Coronária Percutânea
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
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Humans
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Middle aged
Idioma:
En
Revista:
Cardiovasc Revasc Med
Assunto da revista:
ANGIOLOGIA
/
CARDIOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article