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Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies.
Si, Jingwen; Shi, Xiangjun; Sun, Shuhao; Zou, Bin; Li, Yaopeng; An, Dongjie; Lin, Xingyu; Gao, Yan; Long, Fei; Pang, Bo; Liu, Xing; Liu, Tian; Chi, Wenna; Chen, Ligong; Dimitrov, Dimiter S; Sun, Yan; Du, Xinru; Yin, Wen; Gao, Guangxun; Min, Junxia; Wei, Lai; Liao, Xuebin.
Afiliação
  • Si J; School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Beijing Advanced Innovation Center for Human Brain Protection, Tsinghua University, 100084 Beijing, China; Joint Graduate Program of Peking-Tsinghua-NIBS, School of Life
  • Shi X; School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Beijing Advanced Innovation Center for Human Brain Protection, Tsinghua University, 100084 Beijing, China.
  • Sun S; School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Beijing Advanced Innovation Center for Human Brain Protection, Tsinghua University, 100084 Beijing, China.
  • Zou B; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 510060 Guangzhou, China.
  • Li Y; School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Beijing Advanced Innovation Center for Human Brain Protection, Tsinghua University, 100084 Beijing, China.
  • An D; School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Beijing Advanced Innovation Center for Human Brain Protection, Tsinghua University, 100084 Beijing, China.
  • Lin X; Zhuhai Yufan Biotechnologies Co., Ltd, Zhuhai, 519000 Guangdong, China.
  • Gao Y; School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Beijing Advanced Innovation Center for Human Brain Protection, Tsinghua University, 100084 Beijing, China; Department of Central Laboratory, Beijing Obstetrics and Gynec
  • Long F; Xi'an Yufan Biotechnologies Co., Ltd, Xi'an, 710032 Shaanxi, China.
  • Pang B; Department of Clinical Laboratory, Guang'an Men Hospital, China Academy of Chinese Medical Sciences, 100053 Beijing, China.
  • Liu X; Department of Anesthesiology, Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan, China.
  • Liu T; Department of Plastic Surgery, General Hospital of Southern Theater Command, PLA, Guangdong, 510010 Guangzhou, China.
  • Chi W; School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Beijing Advanced Innovation Center for Human Brain Protection, Tsinghua University, 100084 Beijing, China.
  • Chen L; School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Beijing Advanced Innovation Center for Human Brain Protection, Tsinghua University, 100084 Beijing, China.
  • Dimitrov DS; Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, PA 15216, USA.
  • Sun Y; Lanzhou Institute of Husbandry and Pharmaceutical Science of CAAS, Lanzhou, 730050 Gansu, China.
  • Du X; Department of Orthopaedics, Beijing Chao-Yang Hospital, Capita Medical University, 100020 Beijing, China.
  • Yin W; Department of Transfusion Medicine, Xijing Hospital, Air Force Military Medical University, Xi'an, 710032 Shaanxi, China.
  • Gao G; Department of Hematology, Xijing Hospital, Air Force Military Medical University, Xi'an, 710032 Shaanxi, China.
  • Min J; The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University, Hangzhou, 310058 Zhejiang, China.
  • Wei L; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 510060 Guangzhou, China. Electronic address: weil9@mail.sysu.edu.cn.
  • Liao X; School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Beijing Advanced Innovation Center for Human Brain Protection, Tsinghua University, 100084 Beijing, China. Electronic address: liaoxuebin@mail.tsinghua.edu.cn.
Cancer Cell ; 38(4): 551-566.e11, 2020 10 12.
Article em En | MEDLINE | ID: mdl-32860752
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Proteínas Serina-Treonina Quinases / Imunoterapia / Neoplasias Limite: Animals / Humans Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Proteínas Serina-Treonina Quinases / Imunoterapia / Neoplasias Limite: Animals / Humans Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article