Two cases of Type â
¢ collagen glomerulopathy and literature review. / â
¢åè¶åè¾å°çç
2ä¾æ¥éåæç®å¤ä¹ .
Zhong Nan Da Xue Xue Bao Yi Xue Ban
; 45(7): 869-873, 2020 Jul 28.
Article
em En, Zh
| MEDLINE
| ID: mdl-32879092
ABSTRACT
In this paper, 2 cases of collagen Type â
¢ glomerulopathy were analyzed. The clinical manifestations mainly included nephrotic syndrome, proteinuria, hypertension and renal dysfunction. One patient showed that the complement factor H-related protein 5 (CFHR5) gene was likely a disease-causing mutation. The pathological examination of renal tissues showed hyperplasia of mesangial matrix, sub-endothelial insertion, and double-track formation. Immunohistochemistry of Type III collagen was positive. Electron microscopy revealed that massive collagen fibers (40-70 nm in diameter) deposited in the mesangial matrix and basement membrane. As for the follow-up results, the normal renal function had kept steady and the proteinuria was moderate in 1 case treated with angiotensin â
¡ receptor blocker. Due to other system disease, another case developed into acute kidney injury and then received hemodialysis. The clinical manifestations of collagen Type â
¢ glomerulopathy was atypical, the light microscope pathological features were various, and the disease was mainly diagnosed by electron microscopy and immunohistochemistry.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colágeno Tipo III
/
Nefropatias
Limite:
Humans
Idioma:
En
/
Zh
Revista:
Zhong Nan Da Xue Xue Bao Yi Xue Ban
Assunto da revista:
MEDICINA
Ano de publicação:
2020
Tipo de documento:
Article