A framework for designing delivery systems.
Nat Nanotechnol
; 15(10): 819-829, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-32895522
ABSTRACT
The delivery of medical agents to a specific diseased tissue or cell is critical for diagnosing and treating patients. Nanomaterials are promising vehicles to transport agents that include drugs, contrast agents, immunotherapies and gene editors. They can be engineered to have different physical and chemical properties that influence their interactions with their biological environments and delivery destinations. In this Review Article, we discuss nanoparticle delivery systems and how the biology of disease should inform their design. We propose developing a framework for building optimal delivery systems that uses nanoparticle-biological interaction data and computational analyses to guide future nanomaterial designs and delivery strategies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Portadores de Fármacos
/
Sistemas de Liberação de Medicamentos
/
Nanotecnologia
/
Nanopartículas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Nanotechnol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Canadá