Circular RNAs in Immune Response and Viral Infection.
Trends Biochem Sci
; 45(12): 1022-1034, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-32900574
ABSTRACT
Circular RNAs (circRNAs) are a diverse class of RNAs with varying sizes, cellular abundance, and biological functions. Investigations from the past decade have revealed that circRNAs are ubiquitously found in eukaryotes and have defined the different biological roles of circRNAs to illuminate this previously unrecognized class of molecules. In the context of the immune system, immune responses and immune-related diseases alter circRNA expression. More recently, several oncogenic double-stranded DNA viruses have been found to encode circRNAs. In this review, we summarize the current understanding of circRNAs and their emerging functions in immune regulation and autoimmune disorders, and discuss the identification and potential roles of viral circRNAs during infections. Finally, we present promising areas for future investigations in the nascent field of circRNAs.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Viroses
/
RNA Viral
/
RNA Circular
Limite:
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos