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Novel Antibiotics May Be Noninferior but Are They Becoming Less Effective?: a Systematic Review.
Bai, Anthony D; Komorowski, Adam S; Lo, Carson K L; Tandon, Pranav; Li, Xena X; Mokashi, Vaibhav; Cvetkovic, Anna; Findlater, Aidan; Liang, Laurel; Loeb, Mark; Mertz, Dominik.
Afiliação
  • Bai AD; Division of Infectious Diseases, McMaster University, Hamilton, Ontario, Canada anthony.bai@medportal.ca.
  • Komorowski AS; Division of Medical Microbiology, McMaster University, Hamilton, Ontario, Canada.
  • Lo CKL; Division of Infectious Diseases, McMaster University, Hamilton, Ontario, Canada.
  • Tandon P; Global Health Office, McMaster University, Hamilton, Ontario, Canada.
  • Li XX; Division of Infectious Diseases, McMaster University, Hamilton, Ontario, Canada.
  • Mokashi V; Division of Medical Microbiology, McMaster University, Hamilton, Ontario, Canada.
  • Cvetkovic A; Division of Infectious Diseases, McMaster University, Hamilton, Ontario, Canada.
  • Findlater A; Division of Infectious Diseases, McMaster University, Hamilton, Ontario, Canada.
  • Liang L; Division of Infectious Diseases, McMaster University, Hamilton, Ontario, Canada.
  • Loeb M; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
  • Mertz D; Division of Infectious Diseases, McMaster University, Hamilton, Ontario, Canada.
Antimicrob Agents Chemother ; 64(11)2020 10 20.
Article em En | MEDLINE | ID: mdl-32900680
ABSTRACT
Novel antibiotics approved by noninferiority trials may become less effective over time in two scenarios (i) the treatment effect in studies of novel antibiotics may be consistently worse than studies of older antibiotics; (ii) when a decreasingly effective control arm is used in a series of noninferiority trials. Our systematic review of 175 noninferiority antibiotic trials found these scenarios to be rare.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antibacterianos Tipo de estudo: Systematic_reviews Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antibacterianos Tipo de estudo: Systematic_reviews Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Canadá