SARS-CoV-2 Antibody Avidity Responses in COVID-19 Patients and Convalescent Plasma Donors.
J Infect Dis
; 222(12): 1974-1984, 2020 11 13.
Article
em En
| MEDLINE
| ID: mdl-32910175
ABSTRACT
BACKGROUND:
Convalescent plasma therapy is a leading treatment for conferring temporary immunity to COVID-19-susceptible individuals or for use as post-exposure prophylaxis. However, not all recovered patients develop adequate antibody titers for donation and the relationship between avidity and neutralizing titers is currently not well understood.METHODS:
SARS-CoV-2 anti-spike and anti-nucleocapsid IgG titers and avidity were measured in a longitudinal cohort of COVID-19 hospitalized patients (nâ =â 16 individuals) and a cross-sectional sample of convalescent plasma donors (nâ =â 130). Epidemiologic correlates of avidity were examined in donors by linear regression. The association of avidity and a high neutralizing titer (NT) were also assessed in donors using modified Poisson regression.RESULTS:
Antibody avidity increased over duration of infection and remained elevated. In convalescent plasma donors, higher levels of anti-spike avidity were associated with older age, male sex, and hospitalization. Higher NTs had a stronger positive correlation with anti-spike IgG avidity (Spearman ρ = 0.386; Pâ <â .001) than with anti-nucleocapsid IgG avidity (Spearman ρ = 0.211; Pâ =â .026). Increasing levels of anti-spike IgG avidity were associated with high NT (≥160) (adjusted prevalence ratioâ =â 1.58 [95% confidence intervalâ =â 1.19-2.12]), independent of age, sex, and hospitalization.CONCLUSIONS:
SARS-CoV-2 antibody avidity correlated with duration of infection and higher neutralizing titers, suggesting a potential alternative screening parameter for identifying optimal convalescent plasma donors.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina G
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Anticorpos Neutralizantes
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SARS-CoV-2
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COVID-19
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Anticorpos Antivirais
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Afinidade de Anticorpos
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos