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Phase 1 study of mTORC1/2 inhibitor sapanisertib (TAK-228) in advanced solid tumours, with an expansion phase in renal, endometrial or bladder cancer.
Voss, Martin H; Gordon, Michael S; Mita, Monica; Rini, Brian; Makker, Vicky; Macarulla, Teresa; Smith, David C; Cervantes, Andrés; Puzanov, Igor; Pili, Roberto; Wang, Ding; Jalal, Shadia; Pant, Shubham; Patel, Manish R; Neuwirth, Rachel L; Enke, Aaron; Shou, Yaping; Sedarati, Farhad; Faller, Douglas V; Burris, Howard A.
Afiliação
  • Voss MH; Department of Medicine, 300 East 66th Street, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. vossm@mskcc.org.
  • Gordon MS; Oncology Research, HonorHealth Research Institute, 10510 N 92nd St Suite 200, Scottsdale, AZ, 85258, USA.
  • Mita M; Department of Hematology and Oncology, Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute, 8700 Beverly Blvd North Tower, Los Angeles, CA, 90048, USA.
  • Rini B; Cleveland Clinic Foundation, Department of Solid Tumor Oncology, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
  • Makker V; Department of Medicine, 300 East 66th Street, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
  • Macarulla T; Medical Oncology Department, Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology (VHIO), Passeig de la Vall d'Hebron, 119, 129, 08035, Barcelona, Spain.
  • Smith DC; University of Michigan, Department of Internal Medicine, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA.
  • Cervantes A; CIBERONC, Department of Medical Oncology, Biomedical Research Institute INCLIVA, University of Valencia, Avda. Menéndez Pelayo 4 acc., 46010, Valencia, Spain.
  • Puzanov I; Vanderbilt University Medical Center, Department of Medicine, Division of Hematology/Oncology, 1161 21st Ave S, Nashville, TN, 37232, USA.
  • Pili R; Clovis Oncology, San Francisco, CA, USA.
  • Wang D; Indiana University-Simon Cancer Center, Department of Medicine, Division of Hematology/Oncology, 535 Barnhill Drive, Indianapolis, IN, 46202, USA.
  • Jalal S; Henry Ford Health System, Hematology/Oncology, 1 Ford Pl, Detroit, MI, 48202, USA.
  • Pant S; Indiana University Melvin and Bren Simon Cancer Center, Hematology/Oncology, 535 Barnhill Drive, Indianapolis, IN, 46202, USA.
  • Patel MR; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.
  • Neuwirth RL; Florida Cancer Specialists/SCRI, Drug Development Unit, 600 N Cattlemen Rd #200, Sarasota, FL, 34232, USA.
  • Enke A; Biostatistics, Millennium Pharmaceuticals, Inc., 40 Landsdowne Street, Cambridge, MA, 02139, USA.
  • Shou Y; Oncology Clinical Research, Millennium Pharmaceuticals Inc., 40 Landsdowne Street, Cambridge, MA, 02139, USA.
  • Sedarati F; Clovis Oncology, San Francisco, CA, USA.
  • Faller DV; Oncology Clinical Research, Millennium Pharmaceuticals Inc., 40 Landsdowne Street, Cambridge, MA, 02139, USA.
  • Burris HA; Trillium Therapeutics Inc., Cambridge, MA, USA.
Br J Cancer ; 123(11): 1590-1598, 2020 11.
Article em En | MEDLINE | ID: mdl-32913286
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Inibidores de Proteínas Quinases / Serina-Treonina Quinases TOR / Neoplasias Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Cancer Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Inibidores de Proteínas Quinases / Serina-Treonina Quinases TOR / Neoplasias Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Cancer Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos